Evidence map›Paper›PMID 39077377›Full record

ArticleBrain communications2024

Biopsychosocial phenotypes in people with HIV in the CHARTER cohort.

Bin Tang, Ronald J Ellis, Florin Vaida, Anya Umlauf, Donald R Franklin, Raha Dastgheyb, Leah H Rubin, Patricia K Riggs, Jennifer E Iudicello, David B Clifford and 3 more

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bin TangDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Ronald J EllisDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.ORCID https://orcid.org/0000-0003-4931-752X
Florin VaidaDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Anya UmlaufDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Donald R FranklinDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Raha DastgheybDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
Leah H RubinDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
Patricia K RiggsDepartment of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Jennifer E IudicelloDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
David B CliffordDepartment of Neurology, Washington University at St. Louis, St. Louis, MO 63110, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Robert K HeatonDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Scott L LetendreDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.ORCID https://orcid.org/0000-0003-3490-4975

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Biopsychosocial Phenotypes and Potential Mechanisms in CHARTERR01MH125720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLIS, RONALD J., LETENDRE, SCOTT L · 2021 to 2025
$3.7M
NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH125720
6 · The paper itself

Abstract

Neuropsychiatric complications such as neurocognitive impairment and depression are common in people with HIV despite viral suppression on antiretroviral therapy, but these conditions are heterogeneous in their clinical presentations and associated disability. Identifying novel biopsychosocial phenotypes that account for neurocognitive performance and depressive and functional symptoms will better reflect the complexities encountered in clinical practice and may have pathological and therapeutic implications. We classified 1580 people with HIV based on 17 features, including 7 cognitive domains, 4 subscales of the Beck depression inventory-II, 5 components of the patient's assessment of own functioning inventory, and dependence in instrumental and basic activities of daily living. A two-stage clustering procedure consisting of dimension reduction with self-organizing maps and Mahalanobis distance-based

Indexed as

cluster analysiscognitiondaily functioningdepressionHIV

Identifiers

PMID39077377
PMCPMC11285184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.