Evidence map›Paper›PMID 39077112›Full record

ArticleFrontiers in cardiovascular medicine2024

The inotropic and arrhythmogenic effects of acutely increased late I

Theresa Gissibl, Laura Stengel, Daniel Tarnowski, Lars S Maier, Stefan Wagner, Anna-Lena Feder, Can Martin Sag

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Theresa GissiblDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Laura StengelDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Daniel TarnowskiDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Lars S MaierDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Stefan WagnerDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Anna-Lena FederDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.
Can Martin SagDepartment of Internal Medicine II/Cardiology, University Medical Center Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute stimulation of the late sodium current (I Objectives: We aimed to investigate whether the increase of the systolic Ca Methods: We used a transgenic mouse model in which PKARIα was made resistant to oxidative activation by homozygous knock-in replacement of redox-sensitive Cysteine 17 with Serine within the regulatory subunits of PKARIα (KI). ATX-II (at 1 nmol/L) was used to acutely enhance I Results: ATX-II increased I Conclusions: The inotropic and arrhythmogenic effects of acutely increased I

Indexed as

CaMKIIexcitation contraction coupling (ECC)L-type Ca2+ current (ICa)oxidative stressPKARIα

Identifiers

PMID39077112
PMCPMC11284163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.