Evidence map›Paper›PMID 39076998›Full record

ArticleFrontiers in immunology2024

Case report: Characterization of the immunologic and molecular landscape in a unique presentation of invasive lobular carcinoma with concurrent uterine carcinosarcoma treated with immunotherapy.

Courtney J Riedinger, Caprice D Eisele, Ashwini Esnakula, Daniel G Stover, Aharon G Freud, Casey M Cosgrove

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Courtney J RiedingerDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center/James Cancer Hospital, Columbus, OH, United States.
Caprice D EiseleThe Ohio State University, Columbus, OH, United States.
Ashwini EsnakulaDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Daniel G StoverDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center/James Cancer Hospital, Columbus, OH, United States.
Aharon G FreudDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Casey M CosgroveDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center/James Cancer Hospital, Columbus, OH, United States.

Funding

Elucidation of Human Natural Killer Cell DevelopmentR01CA208353 · NCI · OHIO STATE UNIVERSITY · PI AHARON G FREUD · 2017 to 2026
$4.0M
NCI NIH HHS R01 CA208353
6 · The paper itself

Abstract

Invasive lobular breast cancer (ILC) is characterized by a relatively high risk for late recurrence and a unique metastatic pattern with an increased risk for metastasis to gynecologic organs and peritoneum. We present a unique case of recurrent ILC with metastasis to the abdominal peritoneum as well as the uterine myometrium and cervix. Treatment was complicated by the discovery of concomitant uterine carcinosarcoma. This patient was effectively treated with a combination of hormonal therapy for her metastatic ILC and a combination of chemotherapy and immunotherapy for uterine carcinosarcoma. Molecular evaluation revealed a characteristic

Indexed as

Breast NeoplasmsCarcinoma, LobularCarcinosarcomaImmunotherapyUterine NeoplasmsAntigens, CDCadherinsClass I Phosphatidylinositol 3-KinasesFemaleHumansKiller Cells, NaturalMiddle AgedMutationTumor MicroenvironmentAntigens, CDCadherinsCDH1 protein, humanClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humancarcinosarcomaepithelial to mesenchymal (EMT)immunotherapylobular breast cancerNK cell (NKC)

Identifiers

PMID39076998
PMCPMC11284112

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.