ArticleFrontiers in sports and active living2024
5'-UMP inhibited muscle atrophy due to detraining: a randomized, double-blinded, placebo-controlled, parallel-group comparative study.
Article in Frontiers in sports and active living, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effects of deload periods in resistance training on muscle hypertrophy and strength endurance in untrained young men using a randomized within subject design.Scientific reports · 2026Trial
- Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice.Biochemistry and biophysics reports · 2025Article
- Article
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6 authors.
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Abstract
Purpose: A short period of disuse of 1-2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5'-monophosphate (5'-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5'-UMP on disuse muscle atrophy in humans remains unknown. Therefore, the aimed of this study was to explore the effects of 5'-UMP supplementation during detraining on short-term disuse muscle atrophy in healthy men. Methods: Following a 6-week resistance training program on upper arm, healthy men were randomized to either a UMP group ( Results: Both groups showed a significant decrease in muscle thickness at MT70. The relative decrease was greater in the placebo group (2.4 ± 2.8%) than in the UMP group (0.0 ± 2.0%), significantly ( Conclusion: After the hypertrophy, 5'-UMP may prevent muscle atrophy due to the detraining within the first week.
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