ReviewFrontiers in medicine2024
Congenital anomalies of the kidney and urinary tract.
Review in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Impact of maternal health on neonatal and long-term kidney outcomes.Pediatric nephrology (Berlin, Germany) · 2026Review
- How we do it: functional magnetic resonance urography in congenital anomalies of the kidney and urinary tract.Pediatric radiology · 2026Review
- Association of UACR and UPCR with kidney failure: analysis of observational data in children with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Observational
- A review of congenital anomalies of the kidney and urinary tract (CAKUT) in Africa.Annals of medicine and surgery (2012) · 2026Review
- Prognostic stratification in congenital abnormalities of the kidney and urinary tract: beyond the antenatal ultrasound.Childhood kidney diseases · 2026Article
- Clinical and Molecular characteristics of kidney and urinary tract congenital anomalies in a cohort of Egyptian patients using whole-exome sequencing.Molecular biology reports · 2026Article
- Expression of ERK1/2, p38, and JNK in Normal Kidney Development and CAKUT.Medicina (Kaunas, Lithuania) · 2026Article
- The Importance of Molecular Testing in the Diagnosis of Genetic Syndromes with Chronic Kidney Disease: Genotype-Phenotype Correlations.International journal of molecular sciences · 2026Article
- Double blind-ending ureter: diagnostic challenges and robotic-assisted surgical management-case report.The Canadian journal of urology · 2026Article
- Congenital urinary tract dilation: when is it clinically significant and when should it prompt intervention?Frontiers in pediatrics · 2026Article
- From Genes to Malformations: Molecular Mechanisms Driving the Pathogenesis of Congenital Anomalies of the Kidney and Urinary Tract.International journal of molecular sciences · 2025Review
- Antibiotic Resistance Trends in Recurrent Paediatric Urinary Tract Infections: A Five-Year Single-Centre Experience.Children (Basel, Switzerland) · 2025Article
- Gene-Disease Relationships in Kidney Genetics.Seminars in nephrology · 2025Review
- A case of mid-segment ureteral duplication: Uncovering a rare developmental anomaly.Urology case reports · 2025Article
- A Case of Horseshoe Kidney and Autosomal Dominant Polycystic Kidney Disease withJournal of clinical medicine · 2025Article
- Article
- Prenatal diagnosis and postnatal outcomes of congenital kidney and urinary tract anomalies: results from a tertiary center.BMC pregnancy and childbirth · 2025Article
- Article
- Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT).Biomedicines · 2025Review
- Pelvic Ectopic Kidney in an Adult: Robotic-Assisted Surgical Treatment of Unrecognized Ureteropelvic Junction Obstruction.Case reports in surgery · 2025Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) refer to a range of conditions that affect the kidney and urinary tract. These anomalies can be severe, such as kidney agenesis, or milder, such as vesicoureteral reflux. CAKUT affects over 1% of live births and accounts for 40-50% of cases of chronic kidney failure in children. The pathogenesis of CAKUT is caused by various environmental, genetic, and epigenetic factors that disrupt normal nephrogenesis. Environmental factors that can lead to CAKUT include maternal diabetes, obesity, malnutrition, alcohol consumption, or medications affecting kidneys development. Genetic factors can cause an imbalance in the metanephros and the ureteric bud interaction. Defects in specific genes such as PAX2, TBX18, NRIP1, REX, SIX2, BMP4, and chromosome 17 cause CAKUT. Over 50 genes have been identified as the root cause of this condition, with monogenetic variants causing up to 20% of all cases. CAKUTs can be diagnosed through fetal ultrasonography, but some anomalies may remain undetected. GWASs, Next Generation Sequencing for targeted and whole exome DNA sequencing may provide additional diagnostic methods. This review article highlights some the leading factors that cause CAKUT, which adversely affects kidney development and urinary tract function.
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