ReviewReviews in cardiovascular medicine2024
Mechanisms of Vein of Marshall-Related Tachyarrhythmias and the Impact of Ethanol Infusion.
Review in Reviews in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Epicardial Connection as a Resource of Atrial Fibrillation Recurrence After Pulsed Field Ablation: A Case Report.Clinical case reports · 2026Article
- Modified Anatomical Ablation Strategy for Mitral Isthmus.Pacing and clinical electrophysiology : PACE · 2026Article
- Article
- A Novel Intracardiac Echocardiography-Guided Approach for Vein of Marshall Ethanol Infusion in Persistent Atrial Fibrillation Ablation.Cardiovascular therapeutics · 2026Article
- Atrial fibrillation: from pathogenesis to novel treatment options.Molecular biomedicine · 2025Review
- The Marshall Complex in the Human Heart: Embryology, Microanatomy, Autonomic Features and Clinical Implications for Atrial Fibrillation-A State-of-the-Art Narrative Review.Journal of clinical medicine · 2025Review
- Impact of Ethanol Infusion to the Vein of Marshall in Atrial Fibrillation and Atrial Tachycardia.Journal of cardiovascular development and disease · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ligament of Marshall (LOM) is a remnant of the embryonic sinus venosus and the left cardinal vein, containing a combination of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia. Various muscular connections exist between the LOM and the left atrium (LA) and the coronary sinus (CS). The LOM is richly innervated by autonomic nerves, with ganglion cells distributed around it. The unique characteristics of the LOM are responsible for generating focal electrical activities and enable it to serve as a substrate for micro- and macro-reentrant circuits. This, in turn, leads to the initiation and perpetuation of atrial fibrillation (AF) and atrial tachycardia (AT). Endocardial ablation in this region does not consistently succeed due to anatomical constraints within the left lateral LA, including the presence of a thicker and longer mitral isthmus (MI), anatomical variations between the MI and epicardial structures such as the CS and vein of Marshall (VOM) and circumflex artery, and the presence of fibrofatty tissue insulating the LOM. Furthermore, epicardial ablation is challenging for inexperienced institutions because of its invasive nature. Ethanol infusion into the VOM (EI-VOM) represents an effective and safe approach that can be employed in conjunction with radiofrequency ablation to eliminate this arrhythmogenic structure.
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Registered trials
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