Evidence map›Paper›PMID 39076506›Full record

ArticleMedical mycology case reports2024

Disseminated histoplasmosis: Long journey of a febrile young man.

Sudip Kumar Banik, Chowdhury Adnan Sami, Md Mizanur Rahman Khan, Shohael Mahmud Arafat, Abed Hussain Khan

Abstract readCase Reports
In one paragraph

Article in Medical mycology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sudip Kumar BanikDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka; Bangladesh.
Chowdhury Adnan SamiDepartment of Internal Medicine, Evercare Hospital Dhaka, Bangladesh.
Md Mizanur Rahman KhanDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka; Bangladesh.
Shohael Mahmud ArafatDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka; Bangladesh.
Abed Hussain KhanDepartment of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka; Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 19-year-old non-diabetic, non-HIV male presented with eighteen months of fever, weight loss, skin rash and lymphadenopathy. He was treated with anti-tubercular medication for more than twelve months in multiple institutions based on repeated biopsy reports of lymph nodes showing granuloma suggestive of tuberculosis. Before he was diagnosed at Bangabandhu Sheikh Mujib Medical University (BSMMU) with disseminated histoplasmosis at eighteen months of his disease, he already lost twenty kg weight, developed multiple small joint pain, back pain, and cough along with previously mentioned symptoms. Extensive investigations at BSMMU revealed biopsy material from multiple sites showed noncaseating granulomas with Periodic acid-Schiff (PAS) stain positive for budding oval yeast cells, and fungal culture revealed growth of dimorphic fungus suggestive of Histoplasma after three weeks. After treatment with intravenous liposomal amphotericin B with continuous itraconazole, the patient's fever completely subsided, his well-being improved, joint pain reduced, started to gain weight, and skin lesions started to heal. This case serves as a significant reminder that it is imperative to consider alternative diagnoses in patients who fail to show improvement with conventional antitubercular treatment.

Indexed as

BangladeshDisseminated histoplasmosisFungusHistoplasmaPDHPUO

Identifiers

PMID39076506
PMCPMC11284678

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.