Evidence map›Paper›PMID 39076468›Full record

ArticleReviews in cardiovascular medicine2024

Association between IL-2 Receptor and Severe Coronary Artery Calcification in Patients with Coronary Artery Disease.

Chenyang Wang, Sheng Liu, Raimov Kamronbek, Siyao Ni, Kexin Yang, Yunxiao Yang, Daliang Zhou, Can Zhou, Chengqian Yin, Ming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reviews in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenyang WangCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Sheng LiuCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Raimov KamronbekCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Siyao NiCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Kexin YangCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Yunxiao YangCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Daliang ZhouDepartment of Cardiology, First Hospital of Harbin City, 150010 Harbin, Heilongjiang, China.
Can ZhouCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Chengqian YinCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Ming ZhangCenter for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronary artery calcification (CAC) is a crucial marker for coronary atherosclerosis, and the extent of CAC is closely linked to the incidence and progression of cardiovascular diseases. The interleukin-2 (IL-2) receptor (IL-2R), which plays a critical role in mediating the proliferation and differentiation of immune cells, may also be involved in the development of CAC. The study aimed to investigate the relationship between IL-2R and CAC, with the goal of providing new insights into cardiovascular diseases. Methods: In this study, we enrolled 606 patients diagnosed with coronary artery disease to assess CAC. Based on coronary artery calcification score (CACS), patients were divided into two groups: the non-severe CAC group (CACS Results: The results showed that IL-2R levels were significantly higher in patients with severe CAC compared to those with non-severe CAC (383 Conclusions: Our study suggests that IL-2R is independently associated with the occurrence of severe CAC in coronary artery disease (CAD) patients. Additionally, IL-2R may play a crucial role in the development of advanced atherosclerosis. Consequently, therapeutic strategies targeting the IL-2/IL-2R pathway may be effective in preventing or treating CAD.

Indexed as

atherosclerosiscoronary artery calcificationcoronary artery diseaseinterleukin-2 receptor

Identifiers

PMID39076468
PMCPMC11267203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.