Evidence map›Paper›PMID 39076222›Full record

ArticleReviews in cardiovascular medicine2022

Incidence and Outcomes of Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting of a Randomized Controlled Trial: A Blinded End-of-cycle Analysis.

Ahmad Farouk Musa, Jeswant Dillon, Mohamed Ezani Md Taib, Alwi Mohamed Yunus, Abdul Rais Sanusi, Mohd Nazeri Nordin, Julian A Smith

Registry-linked trialAbstract read
In one paragraph

Article in Reviews in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03807037 (Safety of Tocotrienols in Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery), which is not on this map. Cited by 7 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03807037 phase2 / phase3completednot on this map

Safety of Tocotrienols in Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery: A Randomized Controlled Exploratory Trial

TypeinterventionalSponsorMonash University MalaysiaRan2018 to 2021Enrolled250ConditionsAtrial FibrillationArmsTocotrienols, Placebo oral capsule
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmad Farouk MusaJeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, 47500 Subang Jaya, Selangor, Malaysia.
Jeswant DillonDepartment of Cardiothoracic Surgery, National Heart Institute, 50400 Kuala Lumpur, Malaysia.
Mohamed Ezani Md TaibDepartment of Cardiothoracic Surgery, National Heart Institute, 50400 Kuala Lumpur, Malaysia.
Alwi Mohamed YunusDepartment of Cardiothoracic Surgery, National Heart Institute, 50400 Kuala Lumpur, Malaysia.
Abdul Rais SanusiDepartment of Cardiothoracic Surgery, National Heart Institute, 50400 Kuala Lumpur, Malaysia.
Mohd Nazeri NordinDepartment of Cardiothoracic Surgery, National Heart Institute, 50400 Kuala Lumpur, Malaysia.
Julian A SmithDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, 3168 Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective of this study is to analyse the incidence of postoperative atrial fibrillation (POAF), demography, post-operative outcomes including morbidity and mortality, length of Cardiac Intensive Care Unit (CICU) stay, High Dependency Unit (HDU) stay, and total hospital stay in patients undergoing coronary bypass grafting (CABG) at Institut Jantung Negana (IJN). Methods: We conducted a prospective, randomised, controlled trial. We supplied the treatment group with Tocovid capsules and the control group with placebo containing palm superolein. Results: Since January 2019, we have recruited the target population of 250 patients. However, the result is still blinded as we are still analysing blood samples for tocotrienol levels. 89.2% of patients completed the study with a 3.6% mortality and a 7.6% attrition rate. 35.2% of the patients developed POAF, the mean time being 46.06 Conclusions: POAF is associated with a higher incidence of renal failure and death while it increases CICU, HDU, and total hospital stay. It remains to be seen whether Tocovid reduces POAF and its associated sequelae. Clinical Trial Registration: NCT03807037 (Registered on 16 January 2019).

Indexed as

CABGCICU staymorbiditymortalitypostoperative atrial fibrillation (POAF)Tocovidtotal hospital stay

Identifiers

PMID39076222
PMCPMC11273857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.