Evidence map›Paper›PMID 39076058›Full record

ArticleOral diseases2025

Cognitive profile in burning mouth syndrome versus mild cognitive impairment: A comparative study.

Grazia Daniela Femminella, Federica Canfora, Gennaro Musella, Gianluca Scotto Di Tella, Lorenzo Ugga, Giuseppe Pecoraro, Stefania Leuci, Noemi Coppola, Natascia De Lucia, Nelson Mauro Maldonato and 6 more

Abstract readComparative Study
In one paragraph

Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Clinical, cognitive and neuropsychiatric correlates of personality in Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. Article
  5. Burning mouth syndrome: updates on pathogenesis and diagnostic algorithms.Journal of oral & facial pain and headache · 2025
    Review
  6. Exploration of a pain assessment tool on burning mouth syndrome.Journal of oral & facial pain and headache · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Grazia Daniela FemminellaDepartment of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
Federica CanforaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-4610-6690
Gennaro MusellaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Gianluca Scotto Di TellaDepartment of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
Lorenzo UggaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.
Giuseppe PecoraroDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Stefania LeuciDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Noemi CoppolaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Natascia De LuciaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Nelson Mauro MaldonatoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Simone LiguoriDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Massimo AriaDepartment of Economics and Statistics, University of Naples "Federico II", Naples, Italy.
Luca D'AnielloDepartment of Social Sciences, University of Naples "Federico II", Naples, Italy.
Giuseppe RengoDepartment of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
Michele Davide MignognaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Daniela AdamoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-3784-4229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to assess and contrast cognitive and psychological aspects of patients with burning mouth syndrome (BMS-MCI) and geriatric patients (G-MCI) with mild cognitive impairment, focusing on potential predictors like pain, mood disorders, blood biomarkers, and age-related white matter changes (ARWMCs).

methodsThe study enrolled 40 BMS-MCI and 40 geriatric G-MCI, matching them by age, gender, and educational background. Participants underwent psychological, sleepiness, and cognitive assessment including the Mini-Mental State Exam (MMSE), Trail Making Test (TMT), Corsi Block-Tapping Task, Rey Auditory Verbal Learning Test, Copying Geometric Drawings Test, Frontal Assessment Battery, and Digit Cancellation Test.

resultsG-MCI patients exhibited higher ARWMCs scores in right (p = 0.005**) and left (p < 0.001**) temporal regions, which may relate to specific neurodegenerative processes. Conversely, BMS-MCI patients showed higher levels of depression and anxiety and lower MMSE scores(p < 0.001**), also struggling more with tasks requiring processing speed and executive function, as evidenced by their higher TMT-A scores (p < 0.001**).

conclusionsThe study highlights particular deficits in global cognition and processing speed for BMS-MCI. The influence of educational background, pain levels, cholesterol, sleep disturbances, and anxiety on these cognitive assessments underscores the need for personalized therapeutic strategies addressing both cognitive and emotional aspects of MCI.

Indexed as

Burning Mouth SyndromeCognitionCognitive DysfunctionAgedAged, 80 and overAnxietyDepressionFemaleHumansMaleMiddle AgedNeuropsychological Testsanxietyburning mouth syndromedepressionmild cognitive impairmentMMSEpainquality of life

Identifiers

PMID39076058
PMCPMC11976131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.