ArticleMicrobiome2024
High-tannin food enhances spatial memory and scatter-hoarding in rodents via the microbiota-gut-brain axis.
Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Transcriptome analysis of brown adipose tissue in Brandt's vole treated with tannic acid under cold exposure.BMC genomics · 2026Article
- Proteomic Mechanisms of Hepatic- and Cardio-Protection of a Food-Hoarding Hibernator, Tamias sibiricus.Integrative zoology · 2026Article
- Trait Hierarchy and Interactive Effects Govern Seed Fate in Rodent-Mediated Dispersal: Insights from Coat Thickness, Nutrients, and Tannins.Integrative zoology · 2026Article
- Gut Microbiome of Two Rodent Species (Animals : an open access journal from MDPI · 2025Article
- Variation in the gut microbiota of wild Eurasian otter (Lutra lutra) likely reflects diet shifts between snow-free and snow seasons.BMC microbiology · 2025Article
- The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis.Frontiers in microbiology · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundThe mutually beneficial coevolutionary relationships between rodents and plant seeds have been a theme of research in plant-animal relationships. Seed tannins are important secondary metabolites of plants that regulate the food-hoarding behavior of rodents; however, the underlying molecular mechanisms are not yet clear. In this study, we investigated whether and how seed tannins improve spatial memory and regulate the hoarding behavior of Tamias sibiricus by altering their gut microbiota.
resultsWe showed that acorn tannins not only improved spatial memory but also enhanced scatter-hoarding in T. sibiricus. Changes in the composition and function of the gut microbiota in response to tannins from acorns are closely related to these improvements. Metabonomic analyses revealed the role of gut isovaleric acid and isobutyric acid as well as serum L-tryptophan in mediating the spatial memory of T. sibiricus via the gut microbiota. The hippocampal proteome provides further evidence that the microbiota-gut-brain axis regulates spatial memory and scatter-hoarding in animals. Our study is likely the first to report that plant secondary metabolites improve hippocampal function and spatial memory and ultimately modulate food-hoarding behavior via the microbiota-gut-brain axis.
conclusionOur findings may have resolved the long-standing puzzle about the hidden role of plant secondary metabolites in manipulating food-hoarding behavior in rodents via the microbiota-gut-brain axis. Our study is important for better understanding the mutualistic coevolution between plants and animals. Video Abstract.
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