ArticleEuropean journal of medical research2024
The obesity paradox and 90 day mortality in chronic critically ill patients: a cohort study using a large clinical database.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Pediatric post-intensive care malnutrition-risk factors and their association with long-term functional outcomes 1 year after discharge: a retrospective cohort study in Thailand.Acute and critical care · 2026Article
- Effect of Weight-based versus Absolute Norepinephrine Dosing on Mortality Risk in Obese Patients with Septic Shock: An Observational, Multicohort, Retrospective Study.Anesthesiology · 2026Observational
- Association of obesity and nutritional status on early sepsis-associated acute kidney injury in older patients with sepsis.BMC nephrology · 2026Article
- Association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases: a retrospective cohort study using the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Interpreting Resting Energy Expenditure in Critically Ill Patients with Obesity: Clinical Impact of Weight Adjustment.Journal of clinical medicine · 2026Article
- Association of Body Mass Index with 28-Day Mortality in Adult Intensive Care Patients with Sepsis: A Retrospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Elevated body mass index as a prognostic marker in acute liver failure: Implications from a two-decade cohort.World journal of clinical cases · 2025Article
- Comparative Analysis of Sepsis Outcomes Across Body Mass Index Groups: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy.World journal of critical care medicine · 2025Review
- The role of adipose tissue in critical illness-induced skeletal muscle wasting-new considerations for treatment approaches.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database.Cardiovascular diabetology · 2025Article
- The Nutritional Status of Patients with Heart Failure and Its Impact on Patient' Outcomes-The Center's Own Experience.Nutrients · 2025Article
- An interpretable machine learning model for predicting in-hospital mortality in ICU patients with ventilator-associated pneumonia.PloS one · 2025Article
- Association between body mass index and long-term all-cause mortality in critically ill patients without malignant tumors.PloS one · 2025Article
- Impact of in-hospital body mass index variation on 28-day mortality in critically ill surgical patients: a multi-center retrospective analysis.Frontiers in medicine · 2025Article
- Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.Critical care (London, England) · 2024Article
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4 authors.
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Abstract
backgroundThis study investigates the obesity paradox, where obesity is linked to lower mortality in certain patient groups, focusing on its impact on long-term mortality in chronic critically ill (CCI) patients.
methodsWe retrospectively analyzed CCI patients from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database's Intensive Care Unit, categorizing them into six groups based on Body Mass Index (BMI). Using stepwise multivariable Cox regression and restricted cubic spline models, we examined the association between BMI and 90 day mortality, accounting for confounding variables through subgroup analyses.
resultsThe study included 1996 CCI patients, revealing a 90 day mortality of 34.12%. Overweight and obese patients exhibited significantly lower mortality compared to normal-weight individuals. Adjusted analysis showed lower mortality risks in overweight and obese groups (HRs 0.60 to 0.72, p < 0.001). The cubic spline model indicated a negative correlation between BMI and 90 day mortality, with subgroup analyses highlighting interactions with age.
conclusionOur findings confirm the obesity paradox in CCI patients, especially among the elderly (65-85 years) and very elderly (≥ 85 years). The results suggest a beneficial association of higher BMI in older CCI patients, though caution is advised for those under 45.
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