Evidence map›Paper›PMID 39075530›Full record

ArticleStem cell research & therapy2024

miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m

Bang Xiao, Yiqing Zhu, Meng Liu, Meiting Chen, Chao Huang, Dabing Xu, Fang Wang, Shuhan Sun, Jinfeng Huang, Ningxia Sun and 1 more

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Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Bang Xiao *Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Yiqing Zhu *Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Meng Liu *Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Meiting Chen *Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Chao Huang *Department of Anatomy, Institute of Biomedical Engineering, Naval Medical University, Shanghai, 200433, China.
Dabing XuThe Center of Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Fang WangDepartment of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Shuhan SunDepartment of Medical Genetics, Naval Medical University, Shanghai, 200433, China.
Jinfeng HuangDepartment of Medical Genetics, Naval Medical University, Shanghai, 200433, China. jfhuang027@hotmail.com.
Ningxia SunThe Center of Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China. suesunchzh@126.com.
Fu YangDepartment of Medical Genetics, Naval Medical University, Shanghai, 200433, China. yangfusq1997@smmu.edu.cn.ORCID 0000-0003-2459-3923

Funding

Key Technologies Research and Development Program 2022YFA1303900National Natural Science Foundation of China 81971337National Natural Science Foundation of China 82201789National Natural Science Foundation of China 82271662Natural Science Foundation of Shanghai 22ZR1477000
6 · The paper itself

Abstract

backgroundFerroptosis is associated with the pathological progression of hemorrhagic injury and ischemia-reperfusion injury. According to our previous study, exosomes formed through bone marrow mesenchymal stem cells modified with miR-340-3p (MB-exos) can restore damaged endometrium. However, the involvement of ferroptosis in endometrial injury and the effect of MB-exos on ferroptosis remain elusive.

methodsThe endometrial injury rat model was developed. Exosomes were obtained from the supernatants of bone marrow mesenchymal stromal cells (BMSCs) and miR-340/BMSCs through differential centrifugation. We conducted RNA-seq analysis on endometrial tissues obtained from the PBS and MB-exos groups. Ferroptosis was induced in endometrial stromal cells (ESCs) by treating them with erastin or RSL3, followed by treatment with B-exos or MB-exos. We assessed the endometrial total m

resultsWe reveal that MB-exos facilitate the injured endometrium to recover by suppressing ferroptosis in endometrial stromal cells. The injured endometrium showed significantly upregulated N

conclusionsThus, these observations provide new insights regarding the molecular mechanisms responsible for endometrial recovery promotion by MB-exos and highlight m

Indexed as

ExosomesFerroptosisHeme Oxygenase-1Mesenchymal Stem CellsMicroRNAsAdenosineAnimalsEndometriumFemaleHeme Oxygenase (Decyclizing)MethyltransferasesRatsRats, Sprague-DawleyUterusAdenosineHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hmox1 protein, ratMethyltransferasesMettl3 protein, ratMicroRNAsMIRN340-1 microRNA, ratN-methyladenosineEndometrium injuryExosomesFerroptosisHMOX1m6A modificationMETTL3miR-340-3pYTHDF2

Identifiers

PMID39075530
PMCPMC11287883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.