ArticleBMC medicine2024
Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study.Nutrients · 2026Article
- Birth Weight, Adult Fat Distribution, and Type 2 Diabetes Mellitus Risk: Sex-Specific Study in a Large Prospective Cohort.Diabetes & metabolism journal · 2026Article
- A large cohort analysis of metabolic signatures underlying the liver-eye axis.Communications medicine · 2026Article
- Epigenetic regulation of nephrogenesis: from Waddington's landscape to adult disease.American journal of physiology. Renal physiology · 2026Review
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Prenatal famine exposure restricts genetic effects on birth weight with implications for metabolic disease risk.Communications medicine · 2026Article
- Relevance of Milk Composition to Human Longitudinal Growth from Infancy Through Puberty: Facts and Controversies.Nutrients · 2025Review
- The association between early-life famine exposure and adulthood risk of thyroid diseases.Frontiers in nutrition · 2025Article
- Causal impact of genetically determined metabolites on kidney cancer and its subtypes: an integrated mendelian randomization and metabolomic study.American journal of cancer research · 2025Article
- Morphometric analysis of the intergenerational effects of protein restriction on nephron endowment in mice.Heliyon · 2024Article
- Early metabolic and hemodynamic indicators of kidney dysfunction in mice offspring from parental low protein diet.Molecular and cellular pediatrics · 2024Article
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Abstract
backgroundExposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic resonance (NMR) metabolomic profiling to identify the metabolic changes that are associated with survival of prenatal famine exposure during the Dutch Famine at the end of World War II and subsequently assess their link to disease.
methodsNMR metabolomics data were generated from serum in 480 individuals prenatally exposed to famine (mean 58.8 years, 0.5 SD) and 464 controls (mean 57.9 years, 5.4 SD). We tested associations of prenatal famine exposure with levels of 168 individual metabolic biomarkers and compared the metabolic biomarker signature of famine exposure with those of 154 common diseases.
resultsPrenatal famine exposure was associated with higher concentrations of branched-chain amino acids ((iso)-leucine), aromatic amino acid (tyrosine), and glucose in later life (0.2-0.3 SD, p < 3 × 10
conclusionsPrenatal famine exposure is associated with a metabolic biomarker signature that strongly resembles signatures of a diverse set of diseases, an observation that can in part be attributed to a shared involvement of obesity.
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