Observational studyBMC infectious diseases2024
Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio associated with 28-day all-cause mortality in septic patients with coronary artery disease: a retrospective analysis of MIMIC-IV database.
Observational study in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Acute and Chronic Effects of Green Tea Kombucha With and Without Grape Skin Extract on Immune and Oxidative Stress Markers in Beginner Runners: A Randomized Controlled Trial.Journal of food science · 2026Trial
- Clinical Importance of the Inflammatory Prognostic Index in Patients with Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.Journal of clinical biochemistry and nutrition · 2026Article
- Stress Hyperglycemia Ratio and the Risk of Sepsis in Patients With Heart Failure: Retrospective Cohort Study From Medical Information Mart for Intensive Care-IV.JMIR medical informatics · 2026Article
- Association between the monocyte-to-lymphocyte ratio and 28-day all-cause mortality in sepsis-associated delirium patients: a retrospective study and machine learning.BMC infectious diseases · 2026Article
- Predictive Value of Platelet-Based Indexes for Mortality in Sepsis.Biomedicines · 2026Article
- Article
- Early Predictive Value of Peripheral Inflammatory Index Combined with High-Sensitivity Troponin T for Sepsis-Induced Cardiomyopathy.Mediterranean journal of hematology and infectious diseases · 2026Article
- Neutrophil percentage-to-albumin ratio is associated with low muscle mass risk in rheumatoid arthritis: evidence from a hospital-based cohort and NHANES validation.Frontiers in immunology · 2026Article
- Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.Frontiers in medicine · 2026Article
- Development and validation of a sepsis-specific systemic inflammation classification system for mortality prediction.Frontiers in medicine · 2026Article
- The predictive ability of blood-based biomarkers to detect bacteremia in hospitalized neonatal foals.Veterinary journal (London, England : 1997) · 2025Article
- Article
- Exploring the Link Between Inflammatory Biomarkers (SII, SIRI, PLR, NLR, LMR) and Migraine in Young and Early Middle-Aged US Adults: Evidence From NHANES 1999-2004 and Machine Learning Models.Brain and behavior · 2025Article
- Clinical risk score to predict poor coronary collateralization in type 2 diabetic patients with chronic total occlusion.BMC cardiovascular disorders · 2025Observational
- The Combined Prognostic Value of the Systemic Immune-Inflammation Index and LDL-C in Patients with AMI Undergoing PPCI.Journal of inflammation research · 2025Article
- The clinical value of PLR, NLR, and MLR in predicting mortality risk in hospitalized patients.Frontiers in pharmacology · 2025Article
- Inflammation, glucose metabolism, and nutritional markers in relation to all-cause and cardiac mortality among initial hemodialysis patients: a multicenter cohort study.Frontiers in nutrition · 2025Article
- Association between Platelet Count and In-Hospital Mortality in Critical Patients with Multiple Myeloma: A Cohort Study.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundHigh Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), Platelet-to-Lymphocyte Ratio (PLR) were associated with worse prognosis of patients with sepsis. In-hospital mortality has been reported to be higher in patients with coronary artery disease (CAD) and sepsis than those with sepsis alone. However, the relationship between NLR, MLR, PLR and mortality in septic patients with coronary artery disease (CAD) remains unclear. The study aimed to explore the association between NLR, MLR, PLR and 28-day all-cause mortality in septic patients with CAD.
methodsWe performed an observational cohort study of septic patients with CAD from the Medical Information Mart for Intensive Care (MIMIC)-IV database between 2008 and 2019. The patients were categorized by three group (Q1: low levels, Q2: medium levels, Q3: high levels) based on tertiles of NLR, MLR, and PLR. The associations between NLR, MLR, PLR and 28-day all-cause mortality were examined using the Cox proportional hazards model. Subsequently, we applied receiver operating characteristic (ROC) analysis for predicting 28-day mortality in septic patients with CAD by combining NLR, MLR and PLR with the modified sequential organ failure assessment (mSOFA) scores.
resultsOverall 1,175 septic patients with CAD were included in the study. Observed all-cause mortality rates in 28 days were 27.1%. Multivariate Cox proportional hazards regression analysis results showed that 28-day all-cause mortality of septic patients with CAD was significantly related to rising NLR levels (adjusted hazard ratio [aHR]: 1.02; 95% confidence interval [CI]: 1.01-1.02; P < 0.001), MLR levels (aHR: 1.29; 95%CI: 1.18-1.41; P < 0.001), and PLR levels (aHR: 1.0007; 95%CI: 1.0004-1.0011; P < 0.001). Meanwhile, the higher levels (Q3) group of NLR, MLR, and PLR also had a higher risk of 28-day all-cause mortality than the lower (Q1) group. The area under the ROC curve of NLR, MLR, PLR, and mSOFA score were 0.630 (95%CI 0.595-0.665), 0.611 (95%CI 0.576-0.646), 0.601 (95%CI 0.567-0.636) and 0.718 (95%CI 0.689-0.748), respectively. Combining NLR, MLR, and PLR with mSOFA scores may improve ability of predicting 28-day mortality (AUC: 0.737, 95%CI 0.709-0.766).
conclusionHigher levels of NLR, MLR and PLR were associated with 28-day all-cause mortality in septic patients with CAD. Further investigation will be needed to improve understanding of the pathophysiology of this relationship.
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