ArticleBMC infectious diseases2024
North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic.
Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Spatio-temporal forecasting of dengue in the Americas through hybrid mechanistic and data-driven models: Systematic review and meta-analysis.Infectious Disease Modelling · 2026Review
- Two Decades of Dengue in Indonesia: Long-Term Trends in Incidence, Mortality, and Disability-Adjusted Life Years, 2005-2024.Pathogens (Basel, Switzerland) · 2026Article
- Unraveling regional variability in Dengue outbreaks in Brazil: leveraging the Moving Epidemics Method (MEM) and climate data to optimize vector control strategies.PLoS neglected tropical diseases · 2025Article
- A Train-the-Trainer Approach to Build Community Resilience to the Health Impacts of Climate Change in the Dominican Republic.International journal of environmental research and public health · 2025Article
- Unravelling dengue serotype 3 transmission in Brazil: evidence for multiple introductions of the 3III_B.3.2 lineage.Virus evolution · 2025Article
- Introduction of dengue virus serotype 3 in the Afar Region, Ethiopia.Emerging microbes & infections · 2024Article
- A new lineage nomenclature to aid genomic surveillance of dengue virus.PLoS biology · 2024Article
- A new lineage nomenclature to aid genomic surveillance of dengue virus.medRxiv : the preprint server for health sciences · 2024Article
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Abstract
backgroundDengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus's transmission pathways and the impact of climatic factors remains limited. This study aims to elucidate the recent transmission dynamics of the dengue virus (DENV) in the Dominican Republic, utilizing a combination of genomic sequencing and epidemiological data analysis, alongside an examination of historical climate patterns.
methodsWe conducted a comprehensive study involving the genomic sequencing of DENV samples collected from patients across different regions of the Dominican Republic over a two-year period. Phylogenetic analyses were performed to identify the circulation of DENV lineages and to trace transmission pathways. Epidemiological data were integrated to analyze trends in dengue incidence and distribution. Additionally, we integrated historical climate data spanning several decades to assess trends in temperature and their potential impact on DENV transmission potential.
resultsOur results highlight a previously unknown north-south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures.
conclusionThis multidisciplinary study reveals intricate patterns of dengue virus transmission in the Dominican Republic, characterized by the co-circulation of multiple DENV lineages and a novel transmission pathway. The observed correlation between rising temperatures and increased dengue transmission potential emphasizes the need for integrated climate-informed strategies in dengue control efforts. Our findings offer critical insights for public health authorities in the Dominican Republic and similar settings, guiding resource allocation and the development of preparedness strategies to mitigate the impacts of climate change on dengue transmission.
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