Evidence map›Paper›PMID 39075327›Full record

SynthesisJournal of neuro-oncology2024

Gamma knife radiosurgery for orbital cavernous hemangioma: a systematic review and single-arm meta-analysis.

Anuraag Punukollu, Brodus Franklin, Felipe Gutierrez Pineda, Kim Wouters, Lucca Palavani, David Hung-Chi Pan, Hsien-Chung Chen

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anuraag Punukollu *Andhra Medical College, Visakhapatnam, India.
Brodus Franklin *Global Health, Texas Children's Hospital, Houston, TX, USA.
Felipe Gutierrez PinedaDepartment of Neurosurgery, School of Medicine, University of Antioquia, Medellin, Colombia.
Kim WoutersDeparment of psychologie, Open universiteit, Heerlen, Netherlands.
Lucca PalavaniFaculty of Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
David Hung-Chi PanDepartment of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Hsien-Chung ChenDepartment of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. yangcyaa@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGamma knife radiosurgery (GKRS) for orbital cavernous hemangioma (OCH) has emerged as a promising method due to its significant clinical improvement and low incidence of complications. This study aimed to evaluate the safety and efficacy of GKRS for the treatment of OCH.

methodsIn accordance with the PRISMA framework, we searched PubMed, Cochrane Central, and Embase for studies reporting outcomes of GKRS for OCH. Studies reporting complications, visual improvement, proptosis, tumor reduction rate, and tumor progression rate for OCH following GKRS were included.

resultsSix studies, out of 1856 search results, with 100 patients were included. Among them, only 5 minor complications were related to GKRS, including 3 with orbital pain and 2 with periorbital chemosis. Thus, the complication rate was 13% (95% CI, 7-25%). Visual acuity and visual field improvement rates after GKRS were 80% (95% CI, 63-96%) and 71% (95% CI, 47-95%) respectively. Proptosis improved in 94% of cases (95% CI, 83-100%). The tumor reduction rate was 77% after GKRS (95% CI, 69-85%).

conclusionGKRS for OCH appears to be a safe technique, as evidenced by the rate of clinical improvement and radiological improvement. However, studies are limited by an absence of a control group. Additional studies are needed to evaluate the relative efficacy of GKRS as compared with alternative surgical modalities for OCH.

Indexed as

Hemangioma, CavernousOrbital NeoplasmsRadiosurgeryHumansCavernous hemangiomaGamma knife surgeryOrbital tumorStereotactic radiosurgery

Identifiers

PMID39075327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.