Evidence map›Paper›PMID 39075226›Full record

ArticleActa pharmacologica Sinica2025

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice.

Alejandro Serrano, Noelia Casares, Iñaki F Trocóniz, Teresa Lozano, Juan J Lasarte, Sara Zalba, María J Garrido

Abstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alejandro SerranoDepartment of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Noelia CasaresNavarra Institute for Health Research (IdisNA), Pamplona, Spain.
Iñaki F TrocónizDepartment of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Teresa LozanoNavarra Institute for Health Research (IdisNA), Pamplona, Spain.
Juan J LasarteNavarra Institute for Health Research (IdisNA), Pamplona, Spain.
Sara Zalba *Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain. szalbaot@unav.es.
María J Garrido *Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain. mgarrido@unav.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P60, a Foxp3 inhibitory peptide, can hinder the regulatory T cell (Treg) activity and impair tumor proliferation. However, low systemic stability and poor specificity have led to daily dosing to achieve therapeutic effect. Therefore, this study aims to improve P60 stability and specific delivery through its encapsulation in liposomes targeting CD25, constitutively expressed in Tregs. P60 liposomes formulated with DSPE-PEG

Indexed as

Forkhead Transcription FactorsInterleukin-2 Receptor alpha SubunitLiposomesPolyethylene GlycolsT-Lymphocytes, RegulatoryAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMice, Inbred C57BLNanoparticlesPeptidesPhosphatidylethanolamines1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)Forkhead Transcription FactorsFoxp3 protein, mouseIl2ra protein, mouseInterleukin-2 Receptor alpha SubunitLiposomesPeptidesPhosphatidylethanolaminesPolyethylene GlycolsCD25lipid nanoparticlePEG chain lengthspost-insertiontranslation approachTreg cells

Identifiers

PMID39075226
PMCPMC11695603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.