Evidence map›Paper›PMID 39075164›Full record

ArticleCommunications biology2024

Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation.

Yifeng Bu, Jamison Burks, Kun Yang, Jacob Prince, Amir Borna, Christopher L Coe, Alan Simmons, Xin M Tu, Dewleen Baker, Donald Kimball and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yifeng BuDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jamison BurksDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Kun YangDivision of Biostatistics and Bioinformatics, University of California San Diego, La Jolla, CA, 92093, USA.
Jacob PrinceDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Amir BornaQuantum Information Sciences, Sandia National Laboratories, Albuquerque, NM, 87123, USA.
Christopher L CoeDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0001-9335-9060
Alan SimmonsCenter for Stress and Mental Health (CESAMH) VA San Diego, La Jolla, CA, 92093, USA.
Xin M TuDivision of Biostatistics and Bioinformatics, University of California San Diego, La Jolla, CA, 92093, USA.
Dewleen BakerCenter for Stress and Mental Health (CESAMH) VA San Diego, La Jolla, CA, 92093, USA.
Donald KimballDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ramesh RaoDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Vishal ShahQuspin Laboratory Head Quarters, Boulder, CO, 80305, USA.
Mingxiong HuangDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Peter SchwindtQuantum Information Sciences, Sandia National Laboratories, Albuquerque, NM, 87123, USA.ORCID 0000-0002-7570-1229
Todd P ColemanDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Imanuel LermanDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. ilerman@health.ucsd.edu.ORCID 0000-0002-6564-7222

Funding

2016 SETAC Asia/Pacific ConferenceR13ES027302 · NIEHS · SOCIETY/ENVIRONMENTAL TOXICOLOGY/CHEM · PI MENZIE, CHARLES · 2016 to 2016
$6k
CSRD VA I01 CX000499CSRD VA I01 CX002035NIEHS NIH HHS 27302C0038RRD VA I01 RX001988
6 · The paper itself

Abstract

Maintenance of autonomic homeostasis is continuously calibrated by sensory fibers of the vagus nerve and sympathetic chain that convey compound action potentials (CAPs) to the central nervous system. Lipopolysaccharide (LPS) intravenous challenge reliably elicits a robust inflammatory response that can resemble systemic inflammation and acute endotoxemia. Here, we administered LPS intravenously in nine healthy subjects while recording ventral cervical magnetoneurography (vcMNG)-derived CAPs at the rostral Right Nodose Ganglion (RNG) and the caudal Right Carotid Artery (RCA) with optically pumped magnetometers (OPM). We observed vcMNG RNG and RCA neural firing rates that tracked changes in TNF-α levels in the systemic circulation. Further, endotype subgroups based on high and low IL-6 responders segregate RNG CAP frequency (at 30-120 min) and based on high and low IL-10 response discriminate RCA CAP frequency (at 0-30 min). These vcMNG tools may enhance understanding and management of the neuroimmune axis that can guide personalized treatment based on an individual's distinct endophenotype.

Indexed as

InflammationLipopolysaccharidesAction PotentialsAdultCarotid ArteriesFemaleHumansMagnetometryMaleYoung AdultLipopolysaccharides

Identifiers

PMID39075164
PMCPMC11286963

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.