ArticleScientific reports2024
Effect of different delivery modes on intestinal microbiota and immune function of neonates.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neonatal complications in late-preterm and early-term infants: a systematic review of observational studies.The Cochrane database of systematic reviews · 2026Pooled it
- Effect of Supplementation withNutrients · 2026Trial
- Prevalence and associated factors of Helicobacter pylori seropositivity, including mode of delivery, among asymptomatic adolescents in Central Sudan: a community-based cross-sectional study.The Libyan journal of medicine · 2026Article
- Microbial-derived tryptophan metabolites in the infant gut associate with increased risk of asthma following cesarean section.Nature communications · 2026Article
- Current Evidence, Controversies, and the Future of Biotics in the Prevention of Necrotizing Enterocolitis: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Fermented Foods, Functional Nutrition, and Maternal Gut Microbiota During Pregnancy: Molecular Mechanisms and the Maternal-Infant Microbiome Axis.International journal of molecular sciences · 2026Review
- Distinct early gut microbiota patterns by delivery mode within 100 hours of birth.World journal of clinical pediatrics · 2026Article
- Maternal Microbiome in Fetal Programming: A One Health Perspective on Translational Implications for Early-Life Health.Microorganisms · 2026Review
- Harnessing the early-life gut microbiome for sustainable ruminant production.Animal microbiome · 2026Review
- Multi-omics analysis reveals the association of cesarean delivery with altered gut microbial profiles and a Th2-biased immune response in neonates.Journal of translational medicine · 2026Article
- Gastrointestinal consequences of cesarean section birth: A systematic review of short- and long-term effects in infancy and beyond.World journal of clinical pediatrics · 2026Article
- The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors.The Korean journal of internal medicine · 2026Review
- The role of the gut microbiota in obesity-related metabolic diseases in the pediatric population.Pediatric endocrinology, diabetes, and metabolism · 2026Review
- Maternal obesity, diet, and the gut microbiome: implications for offspring cardiometabolic programming.Frontiers in nutrition · 2026Review
- Pathogenesis and intervention strategies for metabolic dysfunction-associated fatty liver disease from the perspective of the gut-microbiota-liver axis.Frontiers in immunology · 2026Review
- Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies.Scientific reports · 2025Article
- The pioneering gut microbiome acquired via different delivery modes in neonates shapes distinct immune and metabolic environments.medRxiv : the preprint server for health sciences · 2025Article
- Associations between multiple perinatal exposures and risk of childhood hospitalisation with infection: a registry-based study in two countries.European journal of epidemiology · 2025Article
- Exploring the multifactorial predictors of stunting in children under five: A systematic review of the literature, 2015-2024.Journal of public health research · 2025Review
- Early-Life Development of the Intestinal Microbiome in Preterm and Term Infants Hospitalized in the Neonatal Intensive Care Unit.Microorganisms · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Different delivery methods can cause variations in the composition and structure of intestinal microbiota in neonates. However, the impact of the microecological environment on host immune function requires further investigation. In this study, 75 healthy neonates were divided into two groups: vaginal delivery group (n = 36) and cesarean section group (n = 39). Fecal and peripheral blood samples were collected from the 7th to the 10th day. 16S rRNA sequencing technique was performed to investigate the gut microbiota on fecal samples. Levels of immunoglobulins and Th1 and Th2 cells in the peripheral blood of neonates were measured. The abundance of Escherichia, Bifidobacterium, and Bacteroides in neonates in the cesarean section group was significantly lower than that in the vaginal delivery group. Metabolic pathway analysis showed three significantly up-regulated metabolic pathways in the intestinal microbiota of neonates in the cesarean section group. The levels of serum IgG and IL-12p70 in the cesarean section group were lower than those in the vaginal delivery group, and the proportion of IFN-γ/IL-4 was significantly lower in the cesarean section group compared to the vaginal delivery group. The mode of delivery has potential impact on the intestinal microbiota and immune functions of neonates, potentially leading to an imbalance of Th1/Th2 cells in neonates delivered by cesarean section.
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