SynthesisScientific reports2024
Depression prevalence of the Geriatric Depression Scale-15 was compared to Structured Clinical Interview for DSM using individual participant data meta-analysis.
Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rates of Depression in Children and Adolescents With ADHD: A Systematic Review and Meta-Analysis.Journal of attention disorders · 2025Pooled it
- The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia.Antioxidants (Basel, Switzerland) · 2026Article
- Depression, but not anxiety, is associated with epigenetic age accelerations among Asian older adults.Molecular psychiatry · 2026Article
- Validation of the Patient Health Questionnaire-2 (PHQ-2) in Detecting Depression Among Older Adults.Aging medicine (Milton (N.S.W)) · 2026Article
- Frailty domains and quality of life associated with geriatric depression in Brazilian primary health care: a cross-sectional study.Scientific reports · 2026Article
- Admission Health Literacy and Depressive Symptoms 3 Months After Discharge in Home-Discharged Acute Stroke Patients: A Prospective Cohort Study.International journal of behavioral medicine · 2026Article
- Article
- Effects of the multidomain non-pharmacological interventions on anxiety symptoms and depressive symptoms in older adults with suspected cognitive impairment: a propensity score matching and difference-in-differences analysis.Frontiers in aging neuroscience · 2026Article
- Relationship of depression and mortality in community-residing elderly individuals: mediating role of frailty and quality of life.BMC geriatrics · 2025Article
- The impact of sociodemographic, health status and health behavior factors on depression and quality of life in older adults.BMC public health · 2025Article
- Observational
- Frailty as a Predictor of Falls in Older Adults with Type 2 Diabetes: Evidence from Vietnam.Clinical interventions in aging · 2025Article
- Association between adolescent life events and depressive symptoms: data from the Shanghai area.Frontiers in psychiatry · 2025Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
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Authors and funding
18 authors.
Funding
Abstract
Depression questionnaire cutoffs are calibrated for screening accuracy and not to assess prevalence, but the Geriatric Depression Scale (GDS-15) is often used to estimate diagnostic prevalence among older adults, most commonly with scores of ≥ 5. We conducted an individual participant data meta-analysis to compare depression prevalence based on GDS-15 ≥ 5 to Structured Clinical Interview for Diagnostic and Statistical Manual (SCID) diagnoses and assessed whether an alternative cutoff could be more accurate. We used generalized linear mixed models to estimate prevalence. Data from 14 studies (3602 participants, 434 SCID major depression) were included. Pooled GDS-15 ≥ 5 prevalence was 34.2% (95% confidence interval [CI] 27.5-41.6%), and pooled SCID prevalence was 14.8% (95% CI 10.0-21.5%; difference of 17.6%, 95% CI 11.6-23.6%). GDS-15 ≥ 8 provided the closest estimate to SCID with mean difference of - 0.3% (95% prediction interval - 17.0-16.5%). Prevalence estimate differences were not associated with study or participant characteristics. In sum, GDS-15 ≥ 5 substantially overestimated depression prevalence. A cutoff of ≥ 8 was accurate overall, but heterogeneity was too high for implementation in practice. Validated diagnostic interviews should be used to estimate major depression prevalence among older adults.
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