Evidence map›Paper›PMID 39075065›Full record

ArticleScientific reports2024

A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts.

Ione Fine, Geoffrey M Boynton

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  2. Article
  3. Review
  4. Evaluating Deep Human-in-the-Loop Optimization for Retinal Implants Using Sighted Participants.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  5. Article
  6. Article
  7. Static or Temporal? Semantic Scene Simplification to Aid Wayfinding in Immersive Simulations of Bionic Vision.Proceedings of the ACM Symposium on Virtual Reality Software and Technology. ACM Symposium on Virtual Reality Software and Technology · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ione FineDepartment of Psychology, University of Washington, Seattle, 98195, USA. ionefine@uw.edu.
Geoffrey M BoyntonDepartment of Psychology, University of Washington, Seattle, 98195, USA.

Funding

The Effects of Attention in Human Visual CortexR01EY012925 · NEI · UNIVERSITY OF WASHINGTON · PI BOYNTON, GEOFFREY M · 1999 to 2018
$5.6M
The Effects of Visual DeprivationR01EY014645 · NEI · UNIVERSITY OF WASHINGTON · PI FINE, IONE · 2004 to 2021
$5.3M
Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologiesR01EY031312 · NEI · UNIVERSITY OF WASHINGTON · PI BOYNTON, GEOFFREY M, FINE, IONE · 2021 to 2025
$2.0M
NEI NIH HHS R01 EY012925NEI NIH HHS R01 EY014645NEI NIH HHS R01 EY031312Office of Extramural Research, National Institutes of Health R01EY014645
6 · The paper itself

Abstract

The field of cortical sight restoration prostheses is making rapid progress with three clinical trials of visual cortical prostheses underway. However, as yet, we have only limited insight into the perceptual experiences produced by these implants. Here we describe a computational model or 'virtual patient', based on the neurophysiological architecture of V1, which successfully predicts the perceptual experience of participants across a wide range of previously published human cortical stimulation studies describing the location, size, brightness and spatiotemporal shape of electrically induced percepts in humans. Our simulations suggest that, in the foreseeable future the perceptual quality of cortical prosthetic devices is likely to be limited by the neurophysiological organization of visual cortex, rather than engineering constraints.

Indexed as

Computer SimulationVisual CortexVisual PerceptionElectric StimulationHumansModels, NeurologicalPhotic StimulationVisual ProsthesisBionic eyeBlindnessCortical prosthesisElectrical stimulationSight recoverySight restoration

Identifiers

PMID39075065
PMCPMC11286872

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.