Evidence map›Paper›PMID 39075057›Full record

ArticleNature communications2024

Widespread exposure to SARS-CoV-2 in wildlife communities.

Amanda R Goldberg, Kate E Langwig, Katherine L Brown, Jeffrey M Marano, Pallavi Rai, Kelsie M King, Amanda K Sharp, Alessandro Ceci, Christopher D Kailing, Macy J Kailing and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Drivers of bat researchers' intent to adopt field hygiene practices.Conservation biology : the journal of the Society for Conservation Biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Amanda R GoldbergDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0003-3094-8241
Kate E LangwigDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0001-8318-1238
Katherine L BrownVirginia Tech Carilion School of Medicine, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0002-6514-8976
Jeffrey M MaranoDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0003-3703-3423
Pallavi RaiDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USA.
Kelsie M KingProgram in Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, USA.
Amanda K SharpProgram in Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, USA.
Alessandro CeciMolecular Diagnostics Laboratory, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0002-9212-5294
Christopher D KailingDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Macy J KailingDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Russell BriggsMolecular Diagnostics Laboratory, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA.
Matthew G UrbanoMolecular Diagnostics Laboratory, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA.
Clinton RobyMolecular Diagnostics Laboratory, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA.
Anne M BrownProgram in Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0001-6951-8228
James Weger-LucarelliCenter for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0002-9483-1694
Carla V Finkielstein *Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. finkielc@vt.edu.ORCID 0000-0002-8417-4643
Joseph R Hoyt *Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. hoytjosephr@gmail.com.ORCID 0000-0003-0398-8264

Funding

National Science Foundation (NSF) DEB-1911853United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service) AP23OA000000C004
6 · The paper itself

Abstract

Pervasive SARS-CoV-2 infections in humans have led to multiple transmission events to animals. While SARS-CoV-2 has a potential broad wildlife host range, most documented infections have been in captive animals and a single wildlife species, the white-tailed deer. The full extent of SARS-CoV-2 exposure among wildlife communities and the factors that influence wildlife transmission risk remain unknown. We sampled 23 species of wildlife for SARS-CoV-2 and examined the effects of urbanization and human use on seropositivity. Here, we document positive detections of SARS-CoV-2 RNA in six species, including the deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, and Eastern red bat between May 2022-September 2023 across Virginia and Washington, D.C., USA. In addition, we found that sites with high human activity had three times higher seroprevalence than low human-use areas. We obtained SARS-CoV-2 genomic sequences from nine individuals of six species which were assigned to seven Pango lineages of the Omicron variant. The close match to variants circulating in humans at the time suggests at least seven recent human-to-animal transmission events. Our data support that exposure to SARS-CoV-2 has been widespread in wildlife communities and suggests that areas with high human activity may serve as points of contact for cross-species transmission.

Indexed as

Animals, WildCOVID-19SARS-CoV-2AnimalsAntibodies, ViralChiropteraDeerDistrict of ColumbiaGenome, ViralHumansPhylogenyRaccoonsRNA, ViralSeroepidemiologic StudiesUrbanizationVirginiaAntibodies, ViralRNA, Viral

Identifiers

PMID39075057
PMCPMC11286844

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.