Evidence map›Paper›PMID 39074896›Full record

ArticleSaudi medical journal2024

The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects.

Mustafa C Durmuşlar, Elif A Gülşen, Kemal A Bayburt, Umut Ballı, Mert Ocak, Ayşegül Fırat, Elham B Zırh, Hakan H Çelik

Abstract read
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In one paragraph

Article in Saudi medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa C DurmuşlarFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.ORCID https://orcid.org/0000-0002-0590-9788
Elif A GülşenFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Kemal A BayburtFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Umut BallıFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Mert OcakFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Ayşegül FıratFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Elham B ZırhFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
Hakan H ÇelikFrom the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the impact of autogenous graft materials, including autogenous bone graft (ABG) and injectable platelet-rich fibrin (I-PRF) clots, on bone defect regeneration in ovariectomized osteoporotic rats.

methodsWistar rats (6-8 weeks old) were ovariectomized, and surgery began after 8 weeks. A 5-mm defect was created bilaterally in the parietal bones of 16 rats, which were divided into 4 groups. Group A (blank) had untreated defects; group B had defects filled with 0.1 ml of I-PRF, group C had defects filled with 0.1 ml of ABG, and group D had defects filled with a combination of 0.1 ml each of I-PRF and ABG. Four weeks post-surgery, the rats were euthanized. Bone regeneration was evaluated through histopathologic analysis and microcomputed tomography (micro-CT).

resultsIn ovariectomized rats treated with ABG or I-PRF, bone regeneration was enhanced, with increased periosteal activity, osteoblast count, and new bone volume, as determined histologically. The ABG+I-PRF group had the highest periosteal vascularity, but the difference compared to the ABG group was not statistically significant (

conclusionThe combined use of ABG and I-PRF enhances bone formation in osteoporotic rats following ovariectomy.

Indexed as

Bone RegenerationBone TransplantationDisease Models, AnimalOsteoporosisOvariectomyPlatelet-Rich FibrinRats, WistarAnimalsFemaleRatsTransplantation, AutologousX-Ray Microtomographyanimal experimentbone regenerationosteoporosisplatelet rich fibrin

Identifiers

PMID39074896
PMCPMC11288487

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