Evidence map›Paper›PMID 39074737›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024

Anti-filarial antibodies are sensitive indicators of lymphatic filariasis transmission and enable identification of high-risk populations and hotspots.

Harriet Lawford, Helen Mayfield, Filipina Amosa-Lei Sam, Satupaitea Viali, Tito Kamu, Gretchen Cooley, Ashley Simon, Diana Martin, Colleen L Lau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harriet LawfordUQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: h.lawford@uq.edu.au.
Helen MayfieldUQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
Filipina Amosa-Lei SamNational University of Samoa, Apia, Samoa; School of Medicine, Faculty of Health Sciences, National University of Samoa.
Satupaitea VialiNational University of Samoa, Apia, Samoa; Oceania University of Medicine, Apia, Samoa.
Tito KamuTupua Tamasese Meaole Hospital, Apia, Samoa.
Gretchen CooleyUS Centers for Disease Control and Prevention, Atlanta, GA, USA; Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ashley SimonUS Centers for Disease Control and Prevention, Atlanta, GA, USA; Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Diana MartinUS Centers for Disease Control and Prevention, Atlanta, GA, USA; Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Colleen L LauUQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCirculating filarial antigen (Ag) is used by elimination programs to monitor lymphatic filariasis (LF) transmission; however, antifilarial antibodies (Ab) may be more sensitive than Ag for detecting LF. Our objectives were to describe Ab seroprevalence, identify risk factors for Ab seropositivity, investigate age-specific associations between Ag and Ab, and evaluate geographic clustering of seropositivity.

methodsCommunity-based serosurveys of participants aged ≥5 years were conducted in 35 primary sampling units (PSUs). Ag-positivity was detected using Alere™ Filariasis Test Strips and Ab-seropositivity using multiplex bead assays. Seroprevalence was adjusted for study design.

resultsOf 3795 participants (range:5-90 years), adjusted prevalence for Ag, Bm14 Ab, Wb123 Ab, and Bm33 Ab were 3.7% (n=117), 20.3% (n=583), 32.2% (n=987), and 51.0% (n=1659), respectively. Male sex, older age, and residents of suspected hotspots had higher odds of seropositivity to all seromarkers. Seroprevalence was lower in 5-9-year-olds vs ≥10-year-olds (P<0.001). Clustering was significantly higher in households (intra-cluster correlation for Ag:0.45; Bm14 Ab:0.32; Bm33 Ab:0.31; Wb123 Ab:0.29) compared to PSUs or region.

conclusionsAbs enabled identification of risk factors for seropositivity and geographical clustering to inform targeted interventions for LF programmes. Further research is needed to define Ab thresholds for active versus past infection and elimination targets.

Indexed as

Antibodies, HelminthAntigens, HelminthElephantiasis, FilarialAdolescentAdultAgedAged, 80 and overAnimalsChildChild, PreschoolDisease HotspotFemaleHumansMaleMiddle AgedPrevalenceAntibodies, HelminthAntigens, HelminthAge-specific associationsAntifilarial antibodiesLymphatic filariasisSamoaSeroprevalence

Identifiers

PMID39074737
PMCPMC11530377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.