Evidence map›Paper›PMID 39074334›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2024

Natural language processing in at-risk mental states: enhancing the assessment of thought disorders and psychotic traits with semantic dynamics and graph theory.

Felipe Argolo, William Henrique de Paula Ramos, Natalia Bezerra Mota, João Medrado Gondim, Ana Caroline Lopes-Rocha, Julio Cesar Andrade, Martinus Theodorus van de Bilt, Leonardo Peroni de Jesus, Andrea Jafet, Guillermo Cecchi and 4 more

Abstract read
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Felipe ArgoloLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
William Henrique de Paula RamosDepartamento de Estatística, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Natalia Bezerra MotaInstituto de Psiquiatria, Departamento de Psiquiatria e Medicina Legal, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Research Department at Motrix Lab, Rio de Janeiro, RJ, Brazil.
João Medrado GondimInstituto de Computação, Universidade Federal da Bahia, Salvador, BA, Brazil.
Ana Caroline Lopes-RochaLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Julio Cesar AndradeLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Martinus Theodorus van de BiltLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
Leonardo Peroni de JesusLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Andrea JafetLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Guillermo CecchiIBM Thomas J. Watson Research Center, Yorktown Heights, NY, USA.
Wagner Farid GattazLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
Cheryl Mary CorcoranIcahn School of Medicine at Mount Sinai, New York, NY, USA. James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.
Anderson AraDepartamento de Estatística, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Alexandre Andrade LochLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 565412/2014-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.625326/2021-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50873-3Wellcome TrustWellcome Trust 223139/Z/21/Z
6 · The paper itself

Abstract

objectiveVerbal communication contains key information for mental health assessment. Researchers have linked psychopathology phenomena to certain counterparts in natural language processing. We characterized subtle impairments in the early stages of psychosis, developing new analysis techniques, which led to a comprehensive map associating features of natural language processing with the full range of clinical presentation.

methodsWe used natural language processing to assess spontaneous and elicited speech by 60 individuals with at-risk mental states and 73 controls who were screened from 4,500 quota-sampled Portuguese speaking residents of São Paulo, Brazil. Psychotic symptoms were independently assessed with the Structured Interview for Psychosis-Risk Syndromes. Speech features (e.g., sentiments and semantic coherence), including novel ones, were correlated with psychotic traits (Spearman's-?) and at-risk mental state status (general linear models and machine-learning ensembles).

resultsNatural language processing features were informative for classification, presenting a balanced accuracy of 86%. Features such as semantic laminarity (as perseveration), semantic recurrence time (as circumstantiality), and average centrality in word repetition graphs carried the most information and were directly correlated with psychotic symptoms. Grammatical tagging (e.g., use of adjectives) was the most relevant standard measure.

conclusionSubtle speech impairments can be detected by sensitive methods and can be used in at-risk mental states screening. We have outlined a blueprint for speech-based evaluation, pairing features to standard psychometric items for thought disorder.

Indexed as

Natural Language ProcessingPsychotic DisordersSemanticsAdolescentAdultBrazilCase-Control StudiesFemaleHumansMalePsychiatric Status Rating ScalesYoung Adultat-risk mental statesmachine learningnatural language processingPsychosisscreeningsemantics

Identifiers

PMID39074334
PMCPMC11773321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.