Evidence map›Paper›PMID 39074333›Full record

ArticleACS biomaterials science & engineering2024

Fresh Carrier for an Old Topical Local Anesthetic: Benzocaine in Nanostructured Lipid Carriers.

A D Souza, G H Rodrigues da Silva, L N M Ribeiro, H Mitsutake, H N Bordallo, M C Breitkreitz, P C Lima Fernandes, L D Moura, F Yokaichiya, M Franco and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A D SouzaDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.
G H Rodrigues da SilvaDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.
L N M RibeiroDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.ORCID 0000-0001-6097-5449
H MitsutakeDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.ORCID 0000-0002-8769-0301
H N BordalloNiels Bohr Institute, University of Copenhagen, ZIP 2100 Copenhagen, Denmark.ORCID 0000-0003-0750-0553
M C BreitkreitzDepartamento de Química Analítica, Instituto de Química, Unicamp, ZIP 13083-862 Campinas, São Paulo, Brazil.
P C Lima FernandesDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.
L D MouraDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.
F YokaichiyaDepartamento de Física, Universidade Federal do Paraná (UFPR), ZIP 81531-980 Curitiba, Paraná, Brazil.
M FrancoInstituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, ZIP 05508-000 São Paulo, São Paulo, Brazil.
E de PaulaDepartamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), ZIP 13083-862 Campinas, São Paulo, Brazil.ORCID 0000-0003-4504-5723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanostructured lipid carriers (NLC) have emerged as innovative drug delivery systems, offering distinct advantages over other lipid-based carriers, such as liposomes and solid lipid nanoparticles. Benzocaine (BZC), the oldest topical local anesthetic in use, undergoes metabolism by pseudocholinesterase, leading to the formation of

Indexed as

Anesthetics, LocalBenzocaineDrug CarriersLipidsAnimalsDrug LiberationMaleMiceNanoparticlesNanostructuresAnesthetics, LocalBenzocaineDrug CarriersLipidsbenzocainedrug deliveryexperimental designlocal anestheticnanostructured lipid carriers

Identifiers

PMID39074333
PMCPMC11322916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.