Evidence map›Paper›PMID 39074308›Full record

ArticleBiomacromolecules2024

Exploring Mucoadhesive and Toxicological Characteristics Following Modification of Linear Polyethylenimine with Various Anhydrides.

Manfei Fu, Roman V Moiseev, Matthew Hyder, Wayne Hayes, Silvia Amadesi, Adrian C Williams, Vitaliy V Khutoryanskiy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manfei FuSchool of Pharmacy, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.
Roman V MoiseevSchool of Pharmacy, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.ORCID 0000-0002-4358-9981
Matthew HyderDepartment of Chemistry, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.ORCID 0000-0001-9458-6898
Wayne HayesDepartment of Chemistry, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.ORCID 0000-0003-0047-2991
Silvia AmadesiSchool of Pharmacy, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.
Adrian C WilliamsSchool of Pharmacy, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.
Vitaliy V KhutoryanskiySchool of Pharmacy, University of Reading, Whiteknights, Post Office Box 224, Reading RG6 6DX, U.K.ORCID 0000-0002-7221-2630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linear polyethylenimine (L-PEI) has numerous applications, such as in pharmaceutical formulations, gene delivery, and water treatment. However, due to the presence of secondary amine groups, L-PEI shows a relatively high toxicity and low biocompatibility. Here, various organic anhydrides were used to modify L-PEI to reduce its toxicity and enhance its functionality. We selected methacrylic anhydride, crotonic anhydride, maleic anhydride, and succinic anhydride to modify L-PEI. The structure of the resulting derivatives was characterized using

Indexed as

AnhydridesPolyethyleneimineAnimalsCattleConjunctivaHumansAnhydridesPolyethyleneimine

Identifiers

PMID39074308
PMCPMC11323015

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.