Evidence map›Paper›PMID 39074288›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation.

Nicholas C Lister, Ashley M Milton, Hardip R Patel, Shafagh A Waters, Benjamin J Hanrahan, Kim L McIntyre, Alexandra M Livernois, William B Horspool, Lee Kian Wee, Alessa R Ringel and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nicholas C ListerSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.ORCID 0000-0002-6597-4784
Ashley M MiltonSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.ORCID 0000-0002-2847-2777
Hardip R PatelJohn Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia.ORCID 0000-0003-3169-049X
Shafagh A WatersSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-1144-5411
Benjamin J HanrahanSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
Kim L McIntyreSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
Alexandra M LivernoisZymeworks, Vancouver, BC V5T 1G4, Canada.
William B HorspoolSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
Lee Kian WeeSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
Alessa R RingelMax Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Stefan MundlosMax Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Michael I RobsonMax Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Linda Shearwin-WhyattSchool of Biological Sciences, University of Adelaide, Adelaide, SA 5000, Australia.
Frank GrütznerSchool of Biological Sciences, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-3088-7314
Jennifer A Marshall GravesDepartment of Environment and Genetics, La Trobe University, Melbourne, VIC 3068, Australia.ORCID 0000-0001-6480-7856
Aurora Ruiz-HerreraDepartament de Biologia Cellular, Fisiologia I Immunologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès 08193, Spain.ORCID 0000-0003-3868-6151
Paul D WatersSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.ORCID 0000-0002-4689-8747

Funding

Department of Education and Training | Australian Research Council (ARC) (DP170101147 DP180100931 DP220101429)Department of Education and Training | Australian Research Council (ARC) DP210103512
6 · The paper itself

Abstract

Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced transcripts of Z genes in chicken. Surprisingly, however, we found that protein abundance ratios were 1:1 between the sexes in both species, indicating a post-transcriptional layer of dosage compensation. We conclude that sex chromosome output is maintained in chicken and platypus (and perhaps many other non therian vertebrates) via a combination of transcriptional and post-transcriptional control, consistent with a critical importance of sex chromosome dosage compensation.

Indexed as

ChickensDosage Compensation, GeneticPlatypusSex ChromosomesAnimalsFemaleMaleRNA, MessengerTranscription, GeneticRNA, Messengerdosage compensationepigeneticpost-transcriptional controlsex chromosome

Identifiers

PMID39074288
PMCPMC11317591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.