ArticleProceedings of the National Academy of Sciences of the United States of America2024
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed.
- The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease.Brain pathology (Zurich, Switzerland) · 2026Article
- Huntingtin and its allies at the cortico-striatal synapse.Cell death & disease · 2026Review
- Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E.Journal of Huntington's disease · 2026Article
- Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics.Neuron · 2025Article
- Evolutionary model of repeat insertions in Ataxin-3 traces the origin of the polyglutamine stretch to an ancestral ubiquitin binding module.Protein science : a publication of the Protein Society · 2024Article
- Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance.International journal of molecular sciences · 2024Article
- Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
21 authors.
Gianna M FoteDepartment of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.
Vinay V EapenDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.
Ryan G LimThe University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.ORCID 0000-0001-6388-5158
Clinton YuDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697.ORCID 0000-0002-2931-5474
Lisa SalazarDepartment of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868.
Nicolette R McClureDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Jharrayne McKnightDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Thai B NguyenDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Marie C HeathDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Alice L LauDepartment of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868.
Mark A VillamilDepartment of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.
Ricardo MiramontesDepartment of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868.
Ian H KratterCenter for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158.
Steven FinkbeinerCenter for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158.
Jack C ReidlingThe University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4291-413X
Peter KaiserDepartment of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.
Lan HuangDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697.ORCID 0000-0002-3140-4687
David E HousmanKoch Institute for Integrative Cancer Research, The Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0001-5016-0756
Leslie M ThompsonDepartment of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.ORCID 0000-0003-4573-9514
Joan S SteffanThe University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.ORCID 0000-0003-2467-6294
Funding
Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells-SupplementU54NS091046 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FINKBEINER, STEVEN M, FRAENKEL, ERNEST · 2014 to 2020
$11.7MTraining in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6MMolecular Mechanisms of Pathogenesis in Huntington’s diseaseR35NS116872 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Leslie Michels Thompson · 2020 to 2026
$8.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1MEpigenetic Pathology and Therapy in Huntington's DiseaseR01NS089076 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FRAENKEL, ERNEST, HOUSMAN, DAVID · 2015 to 2024
$4.9MRare Variant Whole Genome Analysis and iPSC Validation of Putative Genetic Modifiers of Huntington DiseaseR37NS101996 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2017 to 2023
$4.4MSupplement: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome SystemR35GM145249 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lan Huang · 2022 to 2026
$3.2MUbiquitin and Metabolite SignalingR35GM148350 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Peter Kaiser · 2023 to 2026
$2.7MPathogenic Impact of SUMO modification in Huntington's diseaseR01NS052789 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, LESLIE MICHELS · 2006 to 2010
$1.9MNeuroregulatory Mechanisms of PIAS1 and Implications for Huntington's DiseaseR01NS090390 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIDSON, BEVERLY L., THOMPSON, LESLIE MICHELS · 2015 to 2018
$1.8MPathogenic impact of Huntington phosphorylation in Huntington's DiseaseR01NS072453 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI STEFFAN, JOAN SAWYER · 2012 to 2015
$1.3MNeuroregulatory Mechanisms of PIAS1 and Implications for Huntington's DiseaseR56NS090390 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, LESLIE MICHELS · 2014 to 2014
$565kHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM145249HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM148350HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008620HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS090390HHS | NIH | National Institute on Aging (NIA) 1F30AG060704-01A1HHS | NIH | National Institute on Aging (NIA) T32AG000096HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) NS052789HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) NS072453HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) NS091046-01HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) NS116872HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) NSR37101996HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint) R35NS116872NIA NIH HHS F30 AG060704NIA NIH HHS T32 AG000096NIGMS NIH HHS R35 GM145249NIGMS NIH HHS R35 GM148350NIGMS NIH HHS T32 GM008620NINDS NIH HHS R01 NS052789NINDS NIH HHS R01 NS072453NINDS NIH HHS R01 NS089076NINDS NIH HHS R01 NS090390NINDS NIH HHS R35 NS116872NINDS NIH HHS R37 NS101996NINDS NIH HHS R56 NS072453NINDS NIH HHS R56 NS090390NINDS NIH HHS U54 NS091046
Abstract
Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in the
Indexed as
Huntingtin ProteinLysosomesMitochondriaRNA-Binding ProteinsUbiquitinAnimalsAutophagyHumansHuntington DiseaseMiceMitochondrial ProteinsPeptidesProtein BindingHTT protein, humanHuntingtin ProteinMitochondrial ProteinsPeptidesRNA-Binding ProteinsUbiquitinautophagyHuntingtinRNA-binding proteinsubiquitinubiquitin-binding domain
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.