Evidence map›Paper›PMID 39074265›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

The RPD3L deacetylation complex is required for facultative heterochromatin repression in

Colleen C Mumford, Hideki Tanizawa, Elizabeth T Wiles, Kevin J McNaught, Kirsty Jamieson, Kenta Tsukamoto, Eric U Selker

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. The RPD3L deacetylation complex is required for facultative heterochromatin repression inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Colleen C MumfordInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0003-0213-0901
Hideki TanizawaInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0002-2573-2473
Elizabeth T WilesInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0001-7269-7466
Kevin J McNaughtInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0002-6887-3161
Kirsty JamiesonInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Kenta TsukamotoInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Eric U SelkerInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0001-6465-0094

Funding

Control and function of heterochromatin in Neurospora crassaR35GM127142 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2018 to 2022
$2.6M
Control and Function of Histone H3 Lysine 27 Methylation in NeurosporaR01GM093061 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2012 to 2015
$1.1M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM093061HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM127142NIGMS NIH HHS R01 GM093061NIGMS NIH HHS R35 GM127142
6 · The paper itself

Abstract

Repression of facultative heterochromatin is essential for developmental processes in numerous organisms. Methylation of histone H3 lysine 27 (H3K27) by Polycomb repressive complex 2 is a prominent feature of facultative heterochromatin in both fungi and higher eukaryotes. Although this methylation is frequently associated with silencing, the detailed mechanism of repression remains incompletely understood. We utilized a forward genetics approach to identify genes required to maintain silencing at facultative heterochromatin genes in

Indexed as

Fungal ProteinsGene Expression Regulation, FungalHeterochromatinHistonesNeurospora crassaAcetylationGene SilencingHistone DeacetylasesMethylationFungal ProteinsHeterochromatinHistone DeacetylasesHistonesepigeneticsH3K27 methylationhistone modificationpolycomb repressive complextranscriptional silencing

Identifiers

PMID39074265
PMCPMC11317574

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.