Evidence map›Paper›PMID 39074260›Full record

ArticleAdvanced biology2025

Prefrontal Cortex Oxygenation During Exercise in Older Adults with Motoric Cognitive Risk Syndrome.

Kell Grandjean da Costa, Eduardo Bodnariuc Fontes, Alekya Menta, Arthur F Kramer, Roger A Fielding, Joe Verghese, Christopher Kowaleski, Nathan Ward, Kieran F Reid

Registry-linked trialAbstract read
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In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07727577 (Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07727577 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults

TypeinterventionalSponsorColby-Sawyer CollegeRan2026 to 2028Enrolled50ConditionsHealthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain ActivityArmsHigh-Intensity Interval Training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kell Grandjean da CostaSchool of Nursing and Health Sciences, Colby-Sawyer College, New London, NH, 03257, USA.ORCID https://orcid.org/0000-0001-7547-2094
Eduardo Bodnariuc FontesDepartment of Psychology, Tufts University, Medford, MA, 02155, USA.
Alekya MentaDepartment of Psychology, Tufts University, Medford, MA, 02155, USA.
Arthur F KramerDepartment of Psychology, Center for Cognitive and Brain Health, Northeastern University, Boston, MA, 02115, USA.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research on Aging at Tufts University, Boston, MA, 02111, USA.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Christopher KowaleskiHealth and Human Services Department, City of Somerville Council on Aging, Somerville, MA, 02144, USA.
Nathan WardDepartment of Psychology, Tufts University, Medford, MA, 02155, USA.
Kieran F ReidLaboratory of Exercise Physiology and Physical Performance, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
NIA NIH HHS P30 AG031679
6 · The paper itself

Abstract

Motoric cognitive risk syndrome (MCR) is a pre-dementia syndrome characterized by subjective memory complaints and gait impairments that may be related to lower prefrontal cortex (PFC) function. Acute bouts of aerobic exercise are shown to improve PFC function, however, the acute effects of exercise on PFC oxygenation have not yet been examined in MCR. This study aims to characterize the PFC oxygenation responses during acute exercise in older adults with MCR. Nineteen older adults with MCR performed a submaximal cycling exercise protocol. Functional near-infrared spectroscopy (fNIRS) is used to measure concentrations of oxygenated (OxyHb) and deoxygenated (DeoxyHb) hemoglobin from the PFC. There is a trend for increased OxyHb concentrations and decreased DeooxyHb concentrations during exercise. Exercise also induced significant increases in ratings of perceived exertion (RPEs) and heart rate. A significant, positive correlation between PFC OxyHb and RPEs during the cycling exercise are also observed. The findings reveal that PFC oxygenation increases during exercise in an intensity-dependent manner and the subjective perception of exertion is associated with the magnitude of PFC oxygenation. These results suggest that moderate-intensity cycling exercise may have beneficial effects on increasing cerebral blood flow in the PFC of older adults with MCR.

Indexed as

ExerciseOxygenPrefrontal CortexAgedAged, 80 and overFemaleHeart RateHemoglobinsHumansMaleMiddle AgedOxygen ConsumptionOxyhemoglobinsSpectroscopy, Near-InfraredHemoglobinsOxygenOxyhemoglobinsaerobic exerciseagingcerebral oxygenationfunctional near‐infrared spectroscopyhemodynamic responsemotoric cognitive risk syndrome

Identifiers

PMID39074260
PMCPMC13325745

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.