Evidence map›Paper›PMID 39073885›Full record

ArticleBioinformatics (Oxford, England)2024

PhysioFit: a software to quantify cell growth parameters and extracellular fluxes.

Loïc Le Grégam, Yann Guitton, Floriant Bellvert, Stéphanie Heux, Fabien Jourdan, Jean-Charles Portais, Pierre Millard

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. IntegrativemSystems · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Loïc Le GrégamToulouse Biotechnology Institute, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, 31077, France.ORCID 0009-0008-1993-4918
Yann GuittonMetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, 31077, France.
Floriant BellvertToulouse Biotechnology Institute, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, 31077, France.
Stéphanie HeuxToulouse Biotechnology Institute, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, 31077, France.
Fabien JourdanMetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, 31077, France.
Jean-Charles PortaisToulouse Biotechnology Institute, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, 31077, France.
Pierre MillardToulouse Biotechnology Institute, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, 31077, France.ORCID 0000-0002-8136-9963

Funding

ANR MetaboHUB-ANR-11-INBS-0010MetaToul-MetaboHUB (Metabolomics and Fluxomics facilities, Toulouse, France
6 · The paper itself

Abstract

summaryQuantification of growth parameters and extracellular uptake and production fluxes is central in systems and synthetic biology. Fluxes can be estimated using various mathematical models by fitting time-course measurements of the concentration of cells and extracellular substrates and products. A single tool is available to non-computational biologists to calculate extracellular fluxes, but it is hardly interoperable and is limited to a single hard-coded growth model. We present our open-source flux calculation software, PhysioFit, which can be used with any growth model and is interoperable by design. PhysioFit includes some of the most common growth models, and advanced users can implement additional models to calculate extracellular fluxes and other growth parameters for metabolic systems or experimental setups that follow alternative kinetics. PhysioFit can be used as a Python library and offers a graphical user interface for intuitive use by end-users and a command-line interface to streamline integration into existing pipelines. AVAILABILITY AND IMPLEMENTATION: PhysioFit v3 is implemented in Python 3 and was tested on Windows, Unix, and MacOS platforms. The source code and the documentation are freely distributed under GPL3 license at https://github.com/MetaSys-LISBP/PhysioFit/ and https://physiofit.readthedocs.io/.

Indexed as

SoftwareModels, BiologicalSynthetic Biology

Identifiers

PMID39073885
PMCPMC11303505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.