Evidence map›Paper›PMID 39073675›Full record

ArticleObesity surgery2024

Impact of Sleeve Gastrectomy on Brain Structural Integrity.

Emma Gangemi, Claudia Piervincenzi, Carlo Augusto Mallio, Giuseppe Spagnolo, Nikolaos Petsas, Ida Francesca Gallo, Antonella Sisto, Livia Quintiliani, Vincenzo Bruni, Carlo Cosimo Quattrocchi

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Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emma Gangemi *Department of Human Neurosciences, Sapienza University of Rome, Viale Dell'Università 30, 00185, Rome, Italy.
Claudia Piervincenzi *Department of Human Neurosciences, Sapienza University of Rome, Viale Dell'Università 30, 00185, Rome, Italy.
Carlo Augusto MallioUnit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy. c.mallio@policlinicocampus.it.ORCID 0000-0002-0149-0801
Giuseppe SpagnoloUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Nikolaos PetsasDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy.
Ida Francesca GalloUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Antonella SistoClinical Psychological Service, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Livia QuintilianiClinical Psychological Service, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Vincenzo BruniUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Carlo Cosimo QuattrocchiCentre for Medical Sciences-CISMed, University of Trento, Via S. Maria Maddalena 1, 38122, Trento, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPotential brain structural differences in people with obesity (PwO) who achieve over or less than 50% excess weight loss (EWL) after sleeve gastrectomy (SG) are currently unknown. We compared measures of gray matter volume (GMV) and white matter (WM) microstructural integrity of PwO who achieved over or less than 50% EWL after SG with a group of controls with obesity (CwO) without a past history of metabolic bariatric surgery.

methodsSixty-two PwO underwent 1.5 T MRI scanning: 24 who achieved more than 50% of EWL after SG ("group a"), 18 who achieved less than 50% EWL after SG ("group b"), and 20 CwO ("group c"). Voxel-based morphometry and tract-based spatial Statistics analyses were performed to investigate GMV and WM differences among groups. Multiple regression analyses were performed to investigate relationships between structural and psychological measures.

resultsGroup a demonstrated significantly lower GMV loss and higher WM microstructural integrity with respect to group b and c in some cortical regions and several WM tracts. Positive correlations were observed in group a between WM integrity and several psychological measures; the lower the WM integrity, the higher the mental distress, emotional dysregulation, and binge eating behavior.

conclusionThe present results gain a new understanding of the neural mechanisms of outcome in patients who undergo SG. We found limited GMV changes and extensive WM microstructural differences between PwO who achieved over or less than 50% EWL after SG, which may be due to higher vulnerability of WM to the metabolic dysfunction present in PwO.

Indexed as

GastrectomyGray MatterMagnetic Resonance ImagingObesity, MorbidWeight LossWhite MatterAdultBariatric SurgeryBrainFemaleHumansMaleMiddle AgedBrain tractographyDTIMetabolic bariatric surgeryObesitySleeve gastrectomyVoxel-based morphometry

Identifiers

PMID39073675

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.