Evidence map›Paper›PMID 39073616›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus.

Wen-Juan Wang, Hua He, Fang Fang, Xin Liu, Meng-Nan Yang, Zi-Lin Chen, Ting Wu, Rong Huang, Fei Li, Jun Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wen-Juan WangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Hua HeMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Fang FangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Xin LiuMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Meng-Nan YangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Zi-Lin ChenMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Ting WuChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Rong HuangDepartment of Obstetrics and Gynecology, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, Temerty Faculty of Medicine, University of Toronto, Toronto M5G 1X5, Canada.ORCID 0000-0003-2570-9748
Fei LiMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Jun ZhangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.ORCID 0000-0003-1706-1611
Fengxiu OuyangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.ORCID 0000-0003-1980-5928
Zhong-Cheng LuoMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.ORCID 0000-0002-1794-1312

Funding

CIHR 155955Ministry of Science and Technology 2019YFA0802501National Natural Science Foundation of China 81961128023Shanghai Municipal Health Commission 2020CXJQ01Shanghai Municipal Science and Technology Commission 21410713500Shanghai Pujiang Program 22PJD045
6 · The paper itself

Abstract

contextFetuin-B is a hepatokine/adipokine implicated in glucose homeostasis and lipid metabolism.

objectiveWe sought to assess whether cord blood fetuin-B levels are altered in gestational diabetes mellitus (GDM) and the association with fetal growth factors and lipids.

methodsIn a nested, case-control study of 153 pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we assessed cord blood fetuin-B in relation to fetal growth factors and lipids (high-density lipoprotein, low-density lipoprotein [LDL], total cholesterol [TC], and triglycerides).

resultsCord blood fetuin-B concentrations were higher in the newborns of GDM vs euglycemic mothers (mean ± SD: 2.35 ± 0.96 vs 2.05 ± 0.73 mg/L; P = .012), and were positively correlated with LDL (r = 0.239; P < .0001), TC (r = 0.230; P = .0001), insulin-like growth factor-Ⅰ (IGF-Ⅰ) (r = 0.137; P = .023) and IGF-Ⅱ (r = 0.148; P = .014) concentrations. Similar associations were observed adjusting for maternal and neonatal characteristics.

conclusionThe study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of IGF-Ⅰ and IGF-Ⅱ.

Indexed as

Diabetes, GestationalFetal BloodFetuin-BLipidsAdultCase-Control StudiesChinaFemaleHumansInfant, NewbornInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMalePregnancyFetuin-BIGF1 protein, humanInsulin-Like Growth Factor IInsulin-Like Growth Factor IILipidscord bloodfetuin-Bgestational diabetes mellitusIGFLDL

Identifiers

PMID39073616
PMCPMC12012798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.