Evidence map›Paper›PMID 39073506›Full record

ReviewCurrent cardiology reports2024

Obesity Paradox in Transcatheter Aortic Valve Replacement.

Luai Madanat, Ahmad Jabri, Ivan D Hanson, Houman Khalili, Josep Rodés-Cabau, Thomas Pilgrim, Taishi Okuno, Sammy Elmariah, Philippe Pibarot, Pedro Villablanca and 1 more

Abstract readMulticenter StudyReview
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In one paragraph

Review in Current cardiology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luai MadanatWilliam Beaumont University Hospital, Corewell Health East, Royal Oak, MI, USA.
Ahmad JabriDepartment of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
Ivan D HansonWilliam Beaumont University Hospital, Corewell Health East, Royal Oak, MI, USA.
Houman KhaliliFlorida Atlantic University and Memorial Cardiovascular Institute, Hollywood, FL, USA.
Josep Rodés-CabauUniversité Laval/Québec Heart and Lung Institute, Laval, Québec, Canada.
Thomas PilgrimBern University Hospital, Bern, Switzerland.
Taishi OkunoBern University Hospital, Bern, Switzerland.
Sammy ElmariahUniversity of San Francisco, San Francisco, CA, USA.
Philippe PibarotUniversité Laval/Québec Heart and Lung Institute, Laval, Québec, Canada.
Pedro VillablancaDepartment of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
Amr E AbbasWilliam Beaumont University Hospital, Corewell Health East, Royal Oak, MI, USA. Amr.Abbas@corewellhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity paradox in cardiovascular risk prediction has gained increasing attention in recent years. We aimed to investigate the impact of BMI on mortality following transcatheter aortic valve replacement (TAVR).

methodsWe performed a multi-center retrospective analysis of patients with severe aortic stenosis undergoing TAVR. Patients were categorized into: Underweight (BMI < 18.5), normal weight (18.5 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). Multivariate cox-proportional hazard model was used to compare all-cause mortality.

resultsTotal of 6688 patients included (175 underweight, 2252 normal weight, 2368 overweight and 1893 with obesity). Mean age of patients was 81 ± 8 years with 55% males. Patients with obesity had higher prevalence of comorbidities but a lower overall STS score. Mortality at 30-days post-TAVR was lower in the obese population compared to underweight, normal weight, and overweight patients (1.6% vs. 6.9%, 3.6%, and 2.8%, respectively, p < 0.001). Similarly, 3-year mortality was lowest in patients with obesity (17.1% vs. 28.9%, 24.5% and 18.6%, respectively, p < 0.001). On multivariate analysis, long term all-cause mortality at 3-years remained significantly lower in patients with obesity compared to underweight (HR 1.74, 95% CI: 1.30-2.40, p < 0.001) and normal weight (HR: 1.41, 95% CI:1.21-1.63, p < 0.001) but not in overweight patients (HR: 1.10, 95% CI:0.94-1.28, p = 0.240).

conclusionIn conclusion, patients with obesity have improved short and long term mortality following TAVR with an observed progressive increase in mortality with lower BMI ranges.

Indexed as

Aortic Valve StenosisBody Mass IndexObesityTranscatheter Aortic Valve ReplacementAgedAged, 80 and overComorbidityFemaleHumansMaleObesity ParadoxPrevalenceRetrospective StudiesRisk AssessmentRisk FactorsThinnessAll-cause mortalityBMIObesity paradoxTAVR

Identifiers

PMID39073506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.