Evidence map›Paper›PMID 39073502›Full record

ArticleJournal of materials science. Materials in medicine2024

Transdermal delivery of botulinum toxin-A through phosphatidylcholine/cholesterol nanoliposomes for treatment of post-acne scarring.

Lannan Chen, Lei Cui, Jiabing Ran, Zhengrui Liu, Xiongbin Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lannan Chen *Department of Medical Cosmetology, The First Clinical Medical College of China Three Gorges University, Yichang Central People's Hospital, Institute of Medical Cosmetology, China Three Gorges University, Yichang, China.
Lei Cui *Department of Medical Cosmetology, The First Clinical Medical College of China Three Gorges University, Yichang Central People's Hospital, Institute of Medical Cosmetology, China Three Gorges University, Yichang, China. leileicui@126.com.
Jiabing Ran *College of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang, China. jiabingran@outlook.com.ORCID http://orcid.org/0000-0002-8474-7368
Zhengrui LiuDepartment of Medical Cosmetology, The First Clinical Medical College of China Three Gorges University, Yichang Central People's Hospital, Institute of Medical Cosmetology, China Three Gorges University, Yichang, China.
Xiongbin ZhuCollege of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang, China.

Funding

National Natural Science Foundation of China 81603345Natural Science Foundation of Hubei Province 2022CFB824Yichang Natural Science Foundation of China A23-2-004
6 · The paper itself

Abstract

As an acne sequela, post-acne scarring (PSA) has huge negative impact on sufferers' quality of life because of aesthetical embarrassment. Transdermal delivery of botulinum toxin-A (BTXA) is a promising strategy for PAS treatment, but currently reported approaches are far from satisfactory. In this work, phosphatidylcholine/cholesterol (PC/Chol) nanoliposomes were utilized for encapsulation and transdermal delivery of BTXA. The composition, structure, morphology, size, size distribution, etc. of as-prepared BTXA@liposome nanoparticles were investigated in detail. Simulated transdermal delivery assay indicated that the diffusion depth of the BXTA@liposome nanoparticles was nearly 8 times that of pure BTXA and reached 380 μm. 12 facial PSA patients were recruited to evaluate the curative effect of the BTXA@liposome nanoparticles on PSA. Through ECCA (échelle d'évaluation clinique des cicatrices d'acné) scoring and self-evaluation of patients, the resultant data indicated that compared to hyaluronic acid (HA) hydrogel treatment the BTXA@liposome/HA hydrogel treatment could better relieve PSA to some extent but didn't show significant advantage. Further work is needed to verify the feasibility and curative effect of this method in PSA treatment in the future.

Indexed as

Administration, CutaneousBotulinum Toxins, Type ACholesterolLiposomesNanoparticlesPhosphatidylcholinesAdultCicatrixDrug Delivery SystemsFemaleHumansHydrogelsMaleBotulinum Toxins, Type ACholesterolHydrogelsLiposomesPhosphatidylcholines

Identifiers

PMID39073502
PMCPMC11286643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.