Evidence map›Paper›PMID 39073447›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2025

Neural correlates of inattention in adults with ADHD.

Jonathan Laatsch, Frederike Stein, Simon Maier, Swantje Matthies, Esther Sobanski, Barbara Alm, Ludger Tebartz van Elst, Axel Krug, Alexandra Philipsen

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan LaatschDepartment of Psychiatry und Psychotherapy, University Hospital Bonn, Bonn, Germany. jonathan.laatsch@ukbonn.de.ORCID http://orcid.org/0009-0004-5557-8894
Frederike SteinDepartment of Psychiatry und Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-5052-6022
Simon MaierDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID http://orcid.org/0000-0002-7326-7422
Swantje MatthiesDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Esther SobanskiDepartment of Child and Adolescent Psychiatry Lucerne, Lucerne, Switzerland.
Barbara AlmDepartment of Psychiatry and Psychotherapy, Medical Faculty of Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Ludger Tebartz van ElstDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID http://orcid.org/0000-0002-2274-5447
Axel Krug *Department of Psychiatry und Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-0564-2497
Alexandra Philipsen *Department of Psychiatry und Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-6876-518X

Funding

Bundesministerium für Bildung und Forschung 01GV0605; 01GV0606
6 · The paper itself

Abstract

In the last two decades, numerous magnetic resonance imaging (MRI) studies have examined differences in cortical structure between individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy controls. These studies primarily emphasized alterations in gray matter volume (GMV) and cortical thickness (CT). Still, the scientific literature is notably scarce in regard to investigating associations of cortical structure with ADHD psychopathology, specifically inattention within adults with ADHD. The present study aimed to elucidate neurobiological underpinnings of inattention beyond GMV and CT by including cortical gyrification, sulcal depth, and fractal dimension. Building upon the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS), cortical structure parameters were investigated using 141 T1-weighted anatomical scans of adult patients with ADHD. All brain structural analyses were performed using the threshold-free cluster enhancement (TFCE) approach and the Computational Anatomy Toolbox (CAT12) integrated into the Statistical Parametric Mapping Software (Matlab Version R2021a). Results revealed significant correlations of inattention in multiple brain regions. Cortical gyrification was negatively correlated, whereas cortical thickness and fractal dimension were positively associated with inattention. The clusters showed widespread distribution across the cerebral cortex, with both hemispheres affected. The cortical regions most prominently affected included the precuneus, para-, pre-, and postcentral gyri, superior parietal lobe, and posterior cingulate cortex. This study highlights the importance of cortical alterations in attentional processes in adults with ADHD. Further research in this area is warranted to elucidate intricacies of inattention in adults with ADHD to potentially enhance diagnostic accuracy and inform personalized treatment strategies.

Indexed as

AttentionAttention Deficit Disorder with HyperactivityCerebral CortexAdultFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultAttention-deficit/hyperactivity disorderClinical neuroscienceInattentionMagnetic resonance imagingNeural correlates

Identifiers

PMID39073447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.