Evidence map›Paper›PMID 39073431›Full record

ReviewArchives of gynecology and obstetrics2024

Prenatal parvovirus B19 infection.

Karl Oliver Kagan, Markus Hoopmann, Annegret Geipel, Jiri Sonek, Martin Enders

Abstract readReview
In one paragraph

Review in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Transplacental Infection: Frequency, Testing, and Treatment.Deutsches Arzteblatt international · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Is parvovirus B19 infection upsurge in 2023-2024 associated with adverse pregnancy outcome?Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  11. Article
  12. Second trimester soft markers: still worth to be mentioned?Archives of gynecology and obstetrics · 2025
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karl Oliver KaganDepartment of Obstetrics and Gynaecology, University Hospital Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany. KOKagan@gmx.de.ORCID 0000-0003-1497-5143
Markus HoopmannDepartment of Obstetrics and Gynaecology, University Hospital Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany.
Annegret GeipelDepartment of Obstetrics and Prenatal Medicine, University Hospital of Bonn, Bonn, Germany.
Jiri SonekDivision of Maternal Fetal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, USA.
Martin EndersLaboratory Prof. Gisela Enders and Colleagues, Stuttgart, Germany, & German Consulting Laboratory for Parvoviruses, Stuttgart, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parvovirus B19 (B19V) causes erythema infectiosum, a.k.a., fifth disease. This disease primarily affects children. It is generally self-limiting and subsides after 1-2 weeks. In pregnancy, the virus can cross the placenta and result in a fetal infection. This may lead to severe fetal anemia, hydrops fetalis, a miscarriage, or intrauterine fetal death. The risk of long-term sequelae also appears to be increased. About one-third of pregnant women are not immune to B19V and, therefore, are at risk to contract a primary infection. The seroconversion rate during pregnancy is generally around 1-2%. During a primary infection, maternal-fetal transplacental transmission of B19V occurs in about 30-50% of the cases and the risk of fetal infection increases with advancing gestational age. The risk of severe fetal anemia or hydrops is around 3-4% overall and is around 6-7% if the primary infection occurs before 20 weeks' gestation. Fetal monitoring in women with a primary B19V infection includes regular ultrasound examinations looking for evidence of hydrops fetalis and Doppler measurements of the middle cerebral artery peak velocity. Fetal blood sampling is performed if a significant anemia is suspected and, if such is found, an intrauterine blood transfusion is needed. This article provides an overview of the epidemiology, pathogenesis, clinical manifestations, diagnostic methods, and management of B19V infection during pregnancy.

Indexed as

Erythema InfectiosumInfectious Disease Transmission, VerticalParvovirus B19, HumanPregnancy Complications, InfectiousFemaleFetal DiseasesHumansHydrops FetalisParvoviridae InfectionsPregnancyAnemiaHydropsInfectionParvovirus B19Prenatal

Identifiers

PMID39073431
PMCPMC11485125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.