Evidence map›Paper›PMID 39073241›Full record

ArticleHead & neck2025

Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors.

Lisa Nachtsheim, L Jansen, S Shabli, C Arolt, A Quaas, J P Klussmann, M Mayer, P Wolber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisa NachtsheimDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0002-0261-4511
L JansenDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
S ShabliDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
C AroltInstitute of Pathology, Medical Faculty, University of Cologne, Cologne, Germany.
A QuaasInstitute of Pathology, Medical Faculty, University of Cologne, Cologne, Germany.
J P KlussmannDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
M MayerDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
P WolberDepartment of Otorhinolaryngology - Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival.

methodsThis analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan-Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.

results21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive-resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5-year overall survival was 67%, the 5-year disease-free survival was 54%.

conclusionTumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.

Indexed as

Neoplasm Recurrence, LocalSalivary Gland NeoplasmsAdolescentAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesRisk FactorsSurvival Analysisrecurrencerisk factorssalivary gland cancersalivary gland neoplasmssurvival

Identifiers

PMID39073241
PMCPMC11635748

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.