ArticleCNS neuroscience & therapeutics2024
Identifying biomarkers related to motor function in chronic stroke: A fNIRS and TMS study.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Cerebral blood flow alterations and machine learning classification in chronic low back pain using multi-PLD ASL radiomics.Scientific reports · 2026Article
- Associations Between Early Functional Brain Network Topology and 6-Month Upper Limb Motor Outcomes in Stroke Patients.Translational stroke research · 2026Article
- Structural-functional connectivity coupling in motor-brain networks following acute ischemic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Resting-state and task-state fNIRS fusion assessment method for upper limb motor function in stroke patients.Journal of neuroengineering and rehabilitation · 2026Article
- Closed-loop brain-computer interfaces for post-stroke sensorimotor loop restoration.Frontiers in neuroscience · 2026Review
- MEP-Guided Scalp Acupuncture Combined with Repetitive Transcranial Magnetic Stimulation for Post-Stroke Upper Extremity Motor Impairment: A Randomized Controlled Study Protocol.International journal of general medicine · 2026Article
- Article
- Simplified assessment of upper limb dysfunction after stroke: decision tree analysis based on the International Classification of Functioning, Disability and Health.European journal of physical and rehabilitation medicine · 2025Article
- Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Article
- The effectiveness of intermittent theta burst stimulation for upper limb motor recovery after stroke: an exploratory randomized controlled trial.Frontiers in neurology · 2025Article
- Predictive nomogram for post-stroke motor dysfunction using fNIRS.Frontiers in human neuroscience · 2025Article
- Identifying biomarkers related to motor function in chronic stroke: A fNIRS and TMS study.CNS neuroscience & therapeutics · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundUpper limb motor impairment commonly occurs after stroke, impairing quality of life. Brain network reorganization likely differs between subgroups with differing impairment severity. This study explored differences in functional connectivity (FC) and corticospinal tract (CST) integrity between patients with mild/moderate versus severe hemiplegia poststroke to clarify the neural correlates underlying motor deficits.
methodSixty chronic stroke patients with upper limb motor impairment were categorized into mild/moderate and severe groups based on Fugl-Meyer scores. Resting-state FC was assessed using functional near-infrared spectroscopy (fNIRS) to compare connectivity patterns between groups across motor regions. CST integrity was evaluated by inducing motor evoked potentials (MEP) via transcranial magnetic stimulation.
resultsCompared to the mild/moderate group, the severe group exhibited heightened premotor cortex-primary motor cortex (PMC-M1) connectivity (t = 4.56, p < 0.01). Absence of MEP was also more frequent in the severe group (χ
conclusionDistinct patterns of connectivity and corticospinal integrity exist between stroke subgroups with differing impairments. Strengthened connectivity potentially indicates recruitment of additional motor resources to compensate for damage. These findings elucidate the neural correlates underlying motor deficits poststroke and could guide personalized, network-based therapies targeting predictive biomarkers to improve rehabilitation outcomes.
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