Evidence map›Paper›PMID 39073229›Full record

SynthesisTropical medicine & international health : TM & IH2024

Prevalence of non-communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta-analysis.

Yohhei Hamada, Matteo Quartagno, Farihah Malik, Keolebogile Ntshamane, Anna Tisler, Sanjay Gaikwad, Carlos Acuna-Villaorduna, Perumal Kannabiran Bhavani, Bachti Alisjahbana, Katharina Ronacher and 25 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Tropical medicine & international health : TM & IH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Yohhei HamadaInstitute for Global Health, University College London, London, UK.
Matteo QuartagnoMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.
Farihah MalikUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Keolebogile NtshamaneThe Aurum Institute, Johannesburg, South Africa.
Anna TislerInstitute for Global Health, University College London, London, UK.
Sanjay GaikwadBJ Government Medical College and Sassoon General Hospitals, Pune, India.
Carlos Acuna-VillaordunaBoston University Medical Center, Section of Infectious Diseases, Boston, Massachusetts, USA.
Perumal Kannabiran BhavaniICMR-National Institute for Research in Tuberculosis, Chennai, India.
Bachti AlisjahbanaResearch Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjadjaran, Bandung, Indonesia.
Katharina RonacherDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Molecular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Lika AprianiResearch Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjadjaran, Bandung, Indonesia.
Mercedes BecerraSocios En Salud, Lima, Peru.
Alexander L ChuDepartment of Medical Education, Dell Medical School at the University of Texas at Austin, Austin, Texas, USA.
Jacob CreswellStop TB Partnership, Innovations and Grants, Geneva, Switzerland.
Gustavo DiazCentro Internacional de Entrenamiento e Investigaciones Médicas-CIDEIM, Cali, Valle del Cauca, Colombia.
Beatriz E FerroDepartamento de Ciencias Básicas Médicas, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
Jerome T GaleaDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Louis GrandjeanUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Harleen M S GrewalDepartment of Clinical Science, Bergen Integrated Diagnostic Stewardship Cluster, Faculty of Medicine, University of Bergen, Bergen, Norway.
Amita GuptaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Edward C Jones-LópezDivision of Infectious Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Léanie KleynhansDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Molecular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Leonid LeccaSocios En Salud, Lima, Peru.
Peter MacPhersonSchool of Health & Wellbeing, University of Glasgow, Glasgow, UK.
Megan MurrayDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Diana MarínFacultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia.
Blanca I RestrepoSchool of Public Health, University of Texas Health Houston, Brownsville, Texas, USA.
Shri Vijay Bala Yogendra ShivakumarJohns Hopkins Center for Infectious Diseases in India, Pune, India.
Eileen ShuColumbia University, College of Physicians and Surgeons, New York, New York, USA.
Dhanasekaran SivakumaranDepartment of Clinical Science, Bergen Integrated Diagnostic Stewardship Cluster, Faculty of Medicine, University of Bergen, Bergen, Norway.
Luan Nguyen Quang VoFriends for International TB Relief, Ha Noi, Vietnam.
Emily L WebbMRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
Andrew CopasInstitute for Global Health, University College London, London, UK.
Ibrahim AbubakarInstitute for Global Health, University College London, London, UK.
Molebogeng X RangakaInstitute for Global Health, University College London, London, UK.

Funding

The Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1M
Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
The Impact of Diabetes on TB treatment outcomesR01AI097494 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GOLUB, JONATHAN E. · 2013 to 2017
$3.0M
HIV-TB Fogarty Research Training ProgramD43TW009574 · FIC · JOHNS HOPKINS UNIVERSITY · PI BOLLINGER, ROBERT C. · 2013 to 2017
$1.0M
CRDF GlobalFIC NIH HHS D43 TW009574FIC NIH HHS D43 TW010540Government of India's (GOI) Department of Biotechnology (DBT)Indian Council of Medical Research (ICMR)National Institute of Allergy and Infectious Diseases (NIAID)NIAID NIH HHS R01 AI097494NIAID NIH HHS UM1 AI069465Office of AIDS Research (OAR)United States National Institutes of Health (NIH)
6 · The paper itself

Abstract

objectiveTo investigate the prevalence of non-communicable diseases among household contacts of people with tuberculosis.

methodsWe conducted a systematic review and individual participant data meta-analysis. We searched Medline, Embase and the Global Index Medicus from inception to 16 May 2023. We included studies that assessed for at least one non-communicable disease among household contacts of people with clinical tuberculosis. We estimated the non-communicable disease prevalence through mixed effects logistic regression for studies providing individual participant data, and compared it with estimates from aggregated data meta-analyses. Furthermore, we compared age and sex-standardised non-communicable disease prevalence with national-level estimates standardised for age and sex.

resultsWe identified 39 eligible studies, of which 14 provided individual participant data (29,194 contacts). Of the remaining 25 studies, 18 studies reported aggregated data suitable for aggregated data meta-analysis. In individual participant data analysis, the pooled prevalence of diabetes in studies that undertook biochemical testing was 8.8% (95% confidence interval [CI], 5.1%-14.9%, four studies). Age-and sex-standardised prevalence was higher in two studies (10.4% vs. 6.9% and 11.5% vs. 8.4%) than the corresponding national estimates and similar in two studies. Prevalence of diabetes mellitus based on self-report or medical records was 3.4% (95% CI 2.6%-4.6%, 14 studies). Prevalence did not significantly differ compared to estimates from aggregated data meta-analysis. There were limited data for other non-communicable diseases.

conclusionThe prevalence of diabetes mellitus among household contacts was high while that of known diabetes was substantially lower, suggesting the underdiagnosis. tuberculosis household contact investigation offers opportunities to deliver multifaceted interventions to identify tuberculosis infection and disease, screen for non-communicable diseases and address shared risk factors.

Indexed as

Family CharacteristicsNoncommunicable DiseasesTuberculosisHumansPrevalencechronic diseasesdiabetes mellitussystematic reviewtuberculosis

Identifiers

PMID39073229
PMCPMC11368628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.