Evidence map›Paper›PMID 39073182›Full record

ReviewSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2024

Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing.

Xinya Guo, Wei Zhang, Jianyu Lu, Yushu Zhu, Hanlin Sun, Dayuan Xu, Shuyuan Xian, Yuntao Yao, Weijin Qian, Bingnan Lu and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Enhanced wound healing through hydrogel:Iranian journal of basic medical sciences · 2025
    Article
  7. Review
  8. Review
  9. Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xinya GuoSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Wei ZhangDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Jianyu LuDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Yushu ZhuDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Hanlin SunDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Dayuan XuDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Shuyuan XianDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Yuntao YaoShanghai Jiao Tong University School of Medicine, Shanghai, China.
Weijin QianShanghai Jiao Tong University School of Medicine, Shanghai, China.
Bingnan LuShanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiaying ShiShanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoyi DingShanghai Jiao Tong University School of Medicine, Shanghai, China.
Yixu LiDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Xirui TongDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Shichu XiaoDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Runzhi HuangDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.
Shizhao JiDepartment of Burn Surgery, Research Unit of key techniques for treatment of burns and combined burns and trauma injury, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Chinese Academy of Medical Sciences, Shanghai, China.ORCID https://orcid.org/0000-0002-5083-288X

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-076Clinical Key Discipline Project of Shanghai; Shanghai Top Priority Research Center Project 2023ZZ02013Deep Blue Talent Project of Naval Medical University, 234 Academic Climbing Programme of Changhai hospital and Achievements Supportive Fund 2018-CGPZ-B03National Natural Science Foundation of China 81930057 81971836Postdoctoral Fellowship Program of CPSF, Shanghai Rising-Star Program (Sailing Special Program) No. 23YF1458400the Excellent Academic Leader Project of Shanghai Science and Technology Committee 23XD1425000
6 · The paper itself

Abstract

backgroundThe perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti-inflammatory, antioxidant and antimicrobial benefits, containing growth factors that promote wound healing, has evolved over the last few decades from simple skin sheets to high-tech dressings, such as being made into nanocomposites, hydrogels, powders, and electrostatically spun scaffolds. This paper aims to explore the historical development, applications, trends, and research hotspots of hAM in wound healing.

methodsWe examined 2660 publications indexed in the Web of Science Core Collection (WoSCC) from January 1, 1975 to July 12, 2023. Utilizing bibliometric methods, we employed VOSviewer, CiteSpace, and R-bibliometrix to characterize general information, identify development trends, and highlight research hotspots. Subsequently, we identified a collection of high-quality English articles focusing on the roles of human amniotic epithelial stem cells (hAESCs), human amniotic mesenchymal stem cells (hAMSCs), and amniotic membrane (AM) scaffolds in regenerative medicine and tissue engineering.

resultsBibliometric analysis identified Udice-French Research Universities as the most productive affiliation and Tseng S.C.G. as the most prolific author. Keyword analysis, historical direct quotations network, and thematic analysis helped us review the historical and major themes in this field. Our examination included the knowledge structure, global status, trends, and research hotspots regarding the application of hAM in wound healing. Our findings indicate that contemporary research emphasizes the preparation and application of products derived from hAM. Notably, both hAM and the cells isolated from it - hADSCs and hAESCs are prominent and promising areas of research in regenerative medicine and tissue engineering.

conclusionThis research delivers a comprehensive understanding of the knowledge frameworks, global dynamics, emerging patterns, and primary research foci in the realm of hAM applications for wound healing. The field is rapidly evolving, and our findings offer valuable insights for researchers. Future research outcomes are anticipated to be applied in clinical practice, enhancing methods for disease prevention, diagnosis, and treatment.

Indexed as

AmnionBiological DressingsWound HealingEpithelial CellsHumansTissue EngineeringTissue Scaffoldsamniotic membranebibliometricstissue engineeringwound healing

Identifiers

PMID39073182
PMCPMC11283885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.