ArticleESC heart failure2024
Coronary microvascular dysfunction and left heart filling pressures in patients with type 2 diabetes.
Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Exploratory Evaluation of Quantitative Rubidium-82 PET Myocardial Perfusion Parameters: Absolute Blood Flow, Flow Reserve, and Left Ventricular Function in an Arabian Gulf Cohort.Journal of clinical medicine · 2026Article
- Coronary microvascular disease in heart failure with preserved ejection fraction.Physiological reports · 2025Review
- Development and validation of a prediction model of left ventricular systolic dysfunction in type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2025Article
- Coronary microvascular dysfunction and left heart filling pressures in patients with type 2 diabetes.ESC heart failure · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
aimsPatients with type 2 diabetes (T2D) have a high prevalence of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), which in turn leads to an increased risk of hospitalization and death. However, the factors of risk and their relative importance in leading to higher left ventricular filling pressures are still disputed. We sought to clarify the associations of a wide range of invasive and non-invasive risk factors with cardiac filling pressures in high-risk T2D patients. METHODS AND
resultsPatients with T2D at high risk of cardiovascular events were prospectively enrolled in this study. Participants were thoroughly phenotyped including right heart catheterization at rest and during exercise, echocardiography, urinary excretion of albumin (UACR), and quantification of their myocardial blood flow rate (MFR) using cardiac
conclusionsIn patients with type 2 diabetes without known HFpEF but risk factors for cardiovascular disease, myocardial blood flow rate was independently associated with PCWP at rest across the range from normal to abnormal left heart filling pressures. A clinically significant difference of 6 mmHg in PWCP was attributable to differences in MFR in patients with the lowest compared with the highest MFR values. This suggests that strategies than attenuate microvascular dysfunction could slow progression of increased left ventricular left heart filling pressures in patients at increased risk.
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