ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Multimorbidity measures associated with cognitive function among community-dwelling older Chinese adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between Clusters of Multimorbidity and Dementia Risk: A Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- Multimorbidity and Cognitive Function in Community-Dwelling Older Adults in Shanghai: The Mediating Role of Sleep Quality.Journal of sleep research · 2026Article
- Behavioral Components of Life's Essential 8 Are More Strongly Associated with Cognitive Function than Clinical Factors in Chinese Older Adults.International journal of behavioral medicine · 2026Article
- Association of multimorbidity with mortality risk in Chinese senior adults: a population-based cohort study.BMC geriatrics · 2026Article
- Illness perception, family resilience, and emotional distress among hospitalized older adults with multimorbidity in Xinjiang, China: a latent profile and mediation analysis.Frontiers in psychiatry · 2026Article
- Association between multimorbidity and young-onset dementia: a prospective study.BMC public health · 2025Article
- Article
- Cognitive function disparities among atrial fibrillation patients with varying comorbidities.Journal of geriatric cardiology : JGC · 2025Article
- Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study.Aging clinical and experimental research · 2025Article
- A Network Analysis of Food Intake and Cognitive Function in Older Adults with Multimorbidity: A National Cross-Sectional Study.Nutrients · 2025Article
- Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers.Annals of clinical and translational neurology · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiometabolic multimorbidity among middle-aged and older adults in China.BMC public health · 2025Article
- Challenges in multimorbidity and cognitive function studies: A call for rigorous analysis and reporting.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association between the CHG index and cardiometabolic multimorbidity: a nationwide prospective cohort and multi-community cross-sectional study.Frontiers in nutrition · 2025Article
- Multimorbidity measures associated with cognitive function among community-dwelling older Chinese adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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8 authors.
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Abstract
introductionOlder adults with multimorbidity are at high risk of cognitive impairment development. There is a lack of research on the associations between different multimorbidity measures and cognitive function among older Chinese adults living in the community.
methodsWe used the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018 and included data on dementia-free participants aged ≥65 years. Multimorbidity measures included condition counts, multimorbidity patterns, and trajectories. The association of multimorbidity measures with cognitive function was examined by generalized estimating equation and linear and logistic regression models.
resultsAmong 14,093 participants at baseline, 43.2% had multimorbidity. Multimorbidity patterns were grouped into cancer-inflammatory, cardiometabolic, and sensory patterns. Multimorbidity trajectories were classified as "onset-condition," "newly developing," and "severe condition." The Mini-Mental State Examination scores were significantly lower for participants with more chronic conditions, with cancer-inflammatory/cardiometabolic/sensory patterns, and with developing multimorbidity trajectories. DISCUSSION: Condition counts, sensory pattern, cardiometabolic pattern, cancer-inflammatory pattern, and multimorbidity developmental trajectories were prospectively associated with cognitive function. HIGHLIGHTS: Elderly individuals with a higher number of chronic conditions were associated with lower MMSE scores in the Chinese Longitudinal Healthy Longevity Survey data. MMSE scores were significantly lower for participants with specific multimorbidity patterns. Individuals with developing trajectories of multimorbidity were associated with lower MMSE scores and a higher risk of mild cognitive impairment.
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