Evidence map›Paper›PMID 39072821›Full record

ArticleCell proliferation2025

TGFβ-mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound-induced skin fibrosis.

Meimei Yin, Lixiang Sun, Shuai Wu, Jinhang Ma, Wenlu Zhang, Xiaoxuan Ji, Zhichong Tang, Xiaowei Zhang, Yichun Yang, Xinyuan Zhang and 5 more

Abstract read
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Meimei YinState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0003-3718-1944
Lixiang SunState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-0287-4831
Shuai WuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Jinhang MaState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Wenlu ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Xiaoxuan JiState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Zhichong TangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Xiaowei ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-7095-5326
Yichun YangCentral Laboratory, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
Xinyuan ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Jin-Wen HuangDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Shaoluan ZhengDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
Wen-Jie LiuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-8044-5338
Chao JiDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Ling-Juan ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0001-6937-4578

Funding

National Key Research and Development Program of China 2023YFC2508102National Natural Science Foundation of China 81971551National Natural Science Foundation of China 82103702National Natural Science Foundation of China 82373879Postdoctoral science foundation of China 2020M682095
6 · The paper itself

Abstract

Aberrant activation of dermal fibroblasts during wound healing often leads to debilitating fibrotic changes in the skin, such as scleroderma and keloids. However, the underlying cellular and molecular mechanisms remain elusive. Here, we established a wound-induced skin fibrosis (WISF) mouse model in mature adult mice, characterised by excessive deposition of collagen bundles, loss of dermal adipocytes, and enrichment of DPP4

Indexed as

AdipocytesCell DifferentiationFibrosisTransforming Growth Factor betaAnimalsDisease Models, AnimalFibroblastsHumansMaleMiceMice, Inbred C57BLSignal TransductionSkinSkin DiseasesStem CellsWound HealingTransforming Growth Factor beta

Identifiers

PMID39072821
PMCPMC11693572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.