Evidence map›Paper›PMID 39072720›Full record

ArticleEuropean journal of immunology2024

PP2A catalytic subunit alpha is critically required for CD8

Xian Zhou, Meilu Li, Minji Ai, Yanfeng Li, Xingxing Zhu, Michael J Hansen, Jun Zhong, Kenneth L Johnson, Roman Zenka, Akhilesh Pandey and 2 more

Abstract read
In one paragraph

Article in European journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Protein Phosphatase 2A Promotes CD8Research (Washington, D.C.) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xian ZhouDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Meilu LiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Minji AiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Yanfeng LiDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Xingxing ZhuDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Michael J HansenDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Jun ZhongDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-3148-4143
Kenneth L JohnsonProteomics Core, Mayo Clinic, Rochester, Minnesota, USA.
Roman ZenkaProteomics Core, Mayo Clinic, Rochester, Minnesota, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Larry R PeaseDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Hu ZengDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9909-7732

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Context dependent amino acid availability and sensing determines humoral immunityR01AI162678 · NIAID · MAYO CLINIC ROCHESTER · PI Hu Zeng · 2022 to 2026
$2.3M
Immune Checkpoint Inhibition and humoral immune response in systemic autoimmunityR01AR077518 · NIAMS · MAYO CLINIC ROCHESTER · PI ZENG, HU · 2021 to 2025
$1.7M
National Institute of Allergy and Infectious Diseases AI162678NCI NIH HHS P30 CA015083NIAID NIH HHS R01 AI162678NIAMS NIH HHS AR077518NIAMS NIH HHS R01 AR077518
6 · The paper itself

Abstract

Although the functions of tyrosine phosphatases in T-cell biology have been extensively studied, our knowledge on the contribution of serine/threonine phosphatases in T cells remains poor. Protein phosphatase 2A (PP2A) is one of the most abundantly expressed serine/threonine phosphatases. It is important in thymocyte development and CD4

Indexed as

CD8-Positive T-LymphocytesHomeostasisProtein Phosphatase 2AnimalsCell ProliferationIntestinal MucosaLymphocyte ActivationMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMechanistic Target of Rapamycin Complex 1Protein Phosphatase 2ApoptosisBacterial infectionsCD8 T cellsIntestinal immunityPP2A

Identifiers

PMID39072720
PMCPMC11550909

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.