Evidence map›Paper›PMID 39072540›Full record

ArticleJournal of research in health sciences2024

How Do Genetic and Environmental Factors Influence Cardiometabolic Risk Factors? Findings from the Isfahan Twins Study.

Mojgan Gharipour, Minoo Dianatkhah, Shayesteh Jahanfar, Ana Paula Dos Santos Rodrigues, Ava Eftekhari, Noushin Mohammadifard, Nizal Sarrafzadegan, Cesar de Oliveira, Erika Aparecida Silveira

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of research in health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Myokines and mitochondrial function in cardiometabolic diseases.Journal of physiology and biochemistry · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mojgan GharipourHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0001-7397-1172
Minoo DianatkhahIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0001-8092-2045
Shayesteh JahanfarDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, USA.
Ana Paula Dos Santos RodriguesGraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Ava EftekhariInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Noushin MohammadifardIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Nizal SarrafzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0002-6828-2169
Cesar de OliveiraDepartment of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.ORCID 0000-0002-1926-8934
Erika Aparecida SilveiraGraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease-discordant twins are excellent subjects for matched case-control studies as they allow for the control of confounding factors such as age, gender, genetic background, and intrauterine and early environment factors.

methodsPast medical history documentation and physical examination were conducted for all participants. Fasting venous blood samples were taken to measure fasting blood glucose (FBG) and lipid levels. The ACE model, a structural equation model, was used to assess heritability.

resultsThis study included 710 twin pairs (210 monozygotic and 500 dizygotic) ranging in age from 2 to 52 years (mean age: 11.67±10.71 years). The study was conducted using participants from the Isfahan Twin Registry (ITR) in 2017. Results showed that in early childhood (2-6 years), height, weight, and body mass index (BMI) were influenced by shared environmental factors (76%, 75%, and 73%, respectively). In late childhood (7-12 years), hip circumference, waist circumference (WC), and low-density lipoprotein (LDL) cholesterol were found to be highly heritable (90%, 76%, and 64%, respectively). In adolescents, height (94%), neck circumference (85%), LDL-cholesterol (81%), WC (70%), triglycerides (69%), weight (68%), and BMI (65%) were all found to be highly or moderately heritable. In adult twins, arm circumference (97%), weight (86%), BMI (82%), and neck circumference (81%) were highly heritable.

conclusionThis study demonstrates that both genetic and environmental factors play a role in influencing individuals at different stages of their lives. Notably, while certain traits such as obesity have a high heritability during childhood, their heritability tends to decrease as individuals transition into adulthood.

Indexed as

Body Mass IndexCardiometabolic Risk FactorsRegistriesTwins, DizygoticTwins, MonozygoticAdolescentAdultBlood GlucoseCardiovascular DiseasesChildChild, PreschoolCholesterol, LDLCross-Sectional StudiesFemaleGene-Environment InteractionHumansBlood GlucoseCholesterol, LDLBody mass indexCardiometabolic diseasesEnvironmentGeneticsObesityRisk factors

Identifiers

PMID39072540
PMCPMC10999106

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