Evidence map›Paper›PMID 39072041›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.

Lauren Y M Middleton, Erika Walker, Scarlet Cockell, John Dou, Vy K Nguyen, Mitchell Schrank, Chirag J Patel, Erin B Ware, Justin A Colacino, Sung Kyun Park and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lauren Y M MiddletonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9422-2912
Erika WalkerDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Scarlet CockellDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
John DouDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Vy K NguyenMedical School, University of Michigan, Ann Arbor, MI, USA.
Mitchell SchrankDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Chirag J PatelMedical School, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8756-8525
Erin B WareInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Justin A ColacinoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sung Kyun ParkDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9605-6337

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
DNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8M
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type EffectsR01AG072396 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Bakulski, Justin Adam Colacino · 2022 to 2026
$3.7M
The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)R01AG070897 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, PARK, SUNG KYUN · 2021 to 2025
$3.4M
NIA NIH HHS P30 AG072931NIA NIH HHS R01 AG067592NIA NIH HHS R01 AG070897NIA NIH HHS R01 AG072396NIA NIH HHS U01 AG009740NIEHS NIH HHS P30 ES017885NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Cognitive impairment among older adults is a growing public health challenge and environmental chemicals may be modifiable risk factors. A wide array of chemicals has not yet been tested for association with cognition in an environment-wide association framework. In the US National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2011-2014 cross-sectional cycles, cognition was assessed using the Digit Symbol Substitution Test (DSST, scores 0-117) among participants aged 60 years and older. Concentrations of environmental chemicals measured in blood or urine were log

Indexed as

cognitiondementiaenvironmental chemicalsenvironmental epidemiologyexposomeExposome-wide association studyExWASmild cognitive impairmentNHANES

Identifiers

PMID39072041
PMCPMC11275687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.