Evidence map›Paper›PMID 39071998›Full record

ReviewTherapeutic advances in vaccines and immunotherapy2024

Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications.

Ashraf A Tabll, Yasser E Shahein, Mohamed M Omran, Nahla A Hussein, Asmaa El-Shershaby, Ana Petrovic, Marija Glasnovic, Robert Smolic, Martina Smolic

Abstract readReview
In one paragraph

Review in Therapeutic advances in vaccines and immunotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Veterinary research forum : an international quarterly journal · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Latest Findings in Immunoglobulin Y Technologies and Applications.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashraf A TabllMicrobial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Yasser E ShaheinMolecular Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, Egypt.
Mohamed M OmranChemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
Nahla A HusseinMolecular Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, Egypt.
Asmaa El-ShershabyMolecular Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, Egypt.
Ana PetrovicFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.ORCID https://orcid.org/0000-0001-5585-3121
Marija GlasnovicFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Robert SmolicFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Martina SmolicFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their high specificity and scalability, Monoclonal IgY antibodies have emerged as a valuable alternative to traditional polyclonal IgY antibodies. This abstract provides an overview of the production and purification methods of monoclonal IgY antibodies, highlights their advantages over polyclonal IgY antibodies, and discusses their recent applications. Monoclonal recombinant IgY antibodies, in contrast to polyclonal IgY antibodies, offer several benefits. such as derived from a single B-cell clone, monoclonal antibodies exhibit superior specificity, ensuring consistent and reliable results. Furthermore, it explores the suitability of monoclonal IgY antibodies for low- and middle-income countries, considering their cost-effectiveness and accessibility. We also discussed future directions and challenges in using polyclonal IgY and monoclonal IgY antibodies. In conclusion, monoclonal IgY antibodies offer substantial advantages over polyclonal IgY antibodies regarding specificity, scalability, and consistent performance. Their recent applications in diagnostics, therapeutics, and research highlight their versatility.

Indexed as

chicken egg yolk antibodieshybridoma technologyIgY antibodiesimmunodiagnosisimmunotherapymonoclonal antibodiespandemics

Identifiers

PMID39071998
PMCPMC11273732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.